ArticleClinical and experimental immunology2003
Th1 and Th1-inducing cytokines in Salmonella infection.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
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- Sex Differences in Salmonellosis Incidence Rates-An Eight-Country National Data-Pooled Analysis.Journal of clinical medicine · 2021Article
- Leukocytoclastic vasculitis in patients with IL12B or IL12RB1 deficiency: case report and review of the literature.Pediatric rheumatology online journal · 2021Review
- Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo.PLoS pathogens · 2021Article
- Fetal Macrophages Exposed toBiomedicines · 2021Article
- Deletion of theGut microbes · 2020Article
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- Innate Activation of IFN-γ-iNOS Axis During Infection WithFrontiers in immunology · 2020Article
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- Comparative evaluation of Salmonella Typhimurium vaccines derived from UK-1 and 14028S: Importance of inherent virulence.PloS one · 2018Article
- Development of a novel S. Typhi and Paratyphi A outer membrane vesicles based bivalent vaccine against enteric fever.PloS one · 2018Article
- Salmonella infection: Interplay between the bacteria and host immune system.Immunology letters · 2017Review
- Interleukin-10 Production by T and B Cells Is a Key Factor to Promote SystemicFrontiers in immunology · 2017Article
- Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ.Frontiers in microbiology · 2014Review
- Immunological characterization of a gidA mutant strain of Salmonella for potential use in a live-attenuated vaccine.BMC microbiology · 2012Article
- The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.Microbes and infection · 2012Review
- Molecular and cellular characterization of a Salmonella enterica serovar Paratyphi a outbreak strain and the human immune response to infection.Clinical and vaccine immunology : CVI · 2012Article
- Salmonella enterica serovar Typhimurium lacking hfq gene confers protective immunity against murine typhoid.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thl and Thl-inducing cytokines and T cell responses were investigated in human salmonellosis. Serum IFN-gamma, IL-12 and IL-18 levels were increased significantly in patients with salmonellosis. The increase in serum IL-15 and IL-18 levels was more significant and prolonged in patients with the systemic form of salmonellosis than in those with the gastroenteric form. The serum IFN-gamma level was correlated significantly with IL-12 and IL18 levels, and the IL-15 level was correlated significantly with IL-18. Upon stimulation with Salmonella in vitro, mononuclear cells from salmonellosis patients produced significantly higher amounts of IFN-gamma and IL-12 compared with those from healthy controls. Anti-IL-12 moAb or anti-IL18 MoAb significantly inhibited Salmonella-induced IFN-gamma production in vitro. gamma delta T cells expressed significantly higher levels of IFN-gamma mRNA in salmonellosis patients than in healthy controls. The results suggest that Th1-inducing cytokines appear to be involved in the in vivo response against Salmonella infection, promoting IFN-gamma production by alpha beta and gamma delta T cells which plays a protective role against Salmonella.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.