ArticleProceedings of the National Academy of Sciences of the United States of America2003
Store-operated calcium channel regulates the chemotactic behavior of ascidian sperm.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Integrated multi-omics identify key signalling pathways for notochord lumenogenesis in ascidianOpen biology · 2025Article
- CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm.Frontiers in cell and developmental biology · 2023Article
- Mechanisms of Sperm-Egg Interactions: What Ascidian Fertilization Research Has Taught Us.Cells · 2022Review
- Perspectives on Potential Fatty Acid Modulations of Motility Associated Human Sperm Ion Channels.International journal of molecular sciences · 2022Review
- A 40 years journey with fish spermatozoa as companions as I personally experienced it.Fish physiology and biochemistry · 2021Review
- Structure and Function of Ion Channels Regulating Sperm Motility-An Overview.International journal of molecular sciences · 2021Review
- Fertilization of Ascidians: Gamete Interaction, Self/Nonself Recognition and Sperm Penetration of Egg Coat.Frontiers in cell and developmental biology · 2021Review
- Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle.PloS one · 2020Article
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- Na-K-2Cl Cotransporter and Store-Operated CaBiophysical journal · 2019Article
- CaScientific reports · 2018Article
- Phototaxis and chemotaxis of brown algal swarmers.Journal of plant research · 2017Review
- Possible ability of bovine follicular fluid to attract migrating bull spermatozoa.Reproductive medicine and biology · 2017Article
- Chemical and physical guidance of fish spermatozoa into the egg through the micropyle†,‡.Biology of reproduction · 2017Article
- Sperm guidance to the egg finds calcium at the helm.Protoplasma · 2014Review
- T-type calcium channel blockers as neuroprotective agents.Pflugers Archiv : European journal of physiology · 2014Review
- Calcium influx and male fertility in the context of the sperm proteome: an update.BioMed research international · 2014Review
- Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.The Journal of cell biology · 2013Article
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5 authors.
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Abstract
The sperm-activating and -attracting factor released from the eggs of the ascidians Ciona intestinalis and Ciona savignyi requires extracellular Ca(2+) for activating sperm motility and eliciting chemotactic behavior of the activated sperm toward the egg. Here, we show that modulators of the store-operated Ca(2+) channel, SK&F96365, Ni(2+), 2-aminoethoxydiphenylborane, and thapsigargin inhibit the chemotactic behavior of the ascidian sperm; on the other hand, blockers of voltage-dependent Ca(2+) channels did not inhibit the chemotaxis, even though they inhibited the sperm activation operated by voltage-dependent Ca(2+) channels. The blockers of store-operated Ca(2+) channels also inhibited the asymmetrical flagellar beating and turning movements of the ascidian sperm, which are typical signs of sperm chemotaxis. Depletion of internal Ca(2+) stores by thapsigargin induced capacitative Ca(2+) entry into the sperm, which was blocked by SK&F96365. These results suggest that the intracellular Ca(2+) concentration increase through the store-operated Ca(2+) channels induces asymmetrical flagellar movements to establish the chemotactic behavior of the sperm.
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