ArticleJournal of clinical microbiology2003
Stability of serotypes during nasopharyngeal carriage of Streptococcus pneumoniae.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media.Journal of clinical microbiology · 2005Trial
- Prevalence, Antimicrobial Resistance, and Genetic Diversity of Non-TypeableHealth science reports · 2026Review
- Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland.PloS one · 2020Article
- Eavesdropping and crosstalk between secreted quorum sensing peptide signals that regulate bacteriocin production in Streptococcus pneumoniae.The ISME journal · 2018Article
- Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking.PLoS pathogens · 2018Article
- Invasive Disease Caused Simultaneously by Dual Serotypes of Streptococcus pneumoniae.Journal of clinical microbiology · 2018Article
- External Quality Assurance for Laboratory Identification and Capsular Typing of Streptococcus pneumoniae.Scientific reports · 2017Article
- Changes in the Serotype Distribution among Antibiotic Resistant Carriage Streptococcus pneumoniae Isolates in Children after the Introduction of the Extended-Valency Pneumococcal Conjugate Vaccine.Journal of Korean medical science · 2017Article
- Clinical and Epidemiological Evidence of the Red Queen Hypothesis in Pneumococcal Serotype Dynamics.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Risk of invasive pneumococcal disease varies by neighbourhood characteristics: implications for prevention policies.Epidemiology and infection · 2013Article
- Carriage rate and serotypes ofAfrican journal of laboratory medicine · 2013Article
- Estimating rates of carriage acquisition and clearance and competitive ability for pneumococcal serotypes in Kenya with a Markov transition model.Epidemiology (Cambridge, Mass.) · 2012Article
- Article
- Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete.Epidemics · 2010Article
- PspA family fusion proteins delivered by attenuated Salmonella enterica serovar Typhimurium extend and enhance protection against Streptococcus pneumoniae.Infection and immunity · 2009Article
- PCR-based quantitation and clonal diversity of the current prevalent invasive serogroup 6 pneumococcal serotype, 6C, in the United States in 1999 and 2006 to 2007.Journal of clinical microbiology · 2009Article
- Impact of capsular switch on invasive pneumococcal disease incidence in a vaccinated population.PloS one · 2008Article
- Serotype-specific and age-dependent generation of pneumococcal polysaccharide-specific memory B-cell and antibody responses to immunization with a pneumococcal conjugate vaccine.Clinical and vaccine immunology : CVI · 2008Article
- High rates of transmission of and colonization by Streptococcus pneumoniae and Haemophilus influenzae within a day care center revealed in a longitudinal study.Journal of clinical microbiology · 2008Article
- Social mixing with other children during infancy enhances antibody response to a pneumococcal conjugate vaccine in early childhood.Clinical and vaccine immunology : CVI · 2007Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotype changes among natural isolates of Streptococcus pneumoniae are well documented and occur by recombinational exchanges at the capsular biosynthetic locus. However, the frequency with which this phenomenon occurs within the nasopharynx of children is not clear and is likely to be highest in the nasopharynx of children, who have high rates of pneumococcal carriage. A birth cohort of 100 infants was studied, and pneumococci were recovered from nasopharyngeal samples taken at monthly intervals during the first 6 months of life and then at 2-monthly intervals until the age of 2 years. Among the 1,353 nasopharyngeal samples were 523 that contained presumptive pneumococci, and three colonies from each were serotyped. A total of 333 isolates, including all isolates of differing serotypes from the same child, were characterized by multilocus sequence typing. Sixty-eight children carried multiple serotypes during the first 2 years of life. Two children carried a typeable and a nonserotypeable pneumococcus of identical genotype, and five children carried genetically indistinguishable isolates of serotypes 15B and 15C. These isolates were considered, respectively, to be due to loss of capsule expression and the known ability of serotype 15B and 15C pneumococci to interconvert by loss or gain of an acetyl group on the capsular polysaccharide. In all other cases, isolates from the same children that differed in serotype also differed in genotype, indicating the acquisition of a different pneumococcal strain rather than a change in capsular type. There was therefore no evidence in this study for any change of serotype due to recombinational replacements at the capsular locus among the pneumococci carried within the nasopharynges of the children.
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