ArticleJournal of clinical microbiology2003
Culture-independent molecular analysis of microbial constituents of the healthy human outer ear.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 112 citations in OpenAlex.
- Microbiome and its Association with Diseases of the Ear, Nose and Pharynx.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Association between theMicrobiology spectrum · 2025Article
- Approach to the diagnosis and management of dysbiosis.Frontiers in nutrition · 2024Review
- Cholesteatoma has an altered microbiota with a higher abundance ofLaryngoscope investigative otolaryngology · 2022Article
- Analysis of the Microbiome of the Ear Canal in Normal Individuals and Patients with Chronic Otitis Externa.Annals of dermatology · 2022Article
- An Overview of Adenoid Microbiome Using 16S rRNA Gene Sequencing-Based Metagenomic Analysis.Medicina (Kaunas, Lithuania) · 2022Article
- Tool and techniques study to plant microbiome current understanding and future needs: an overview.Communicative & integrative biology · 2022Review
- Article
- Association of Skin Microbiome with the Onset and Recurrence of Pressure Injury in Bedridden Elderly People.Microorganisms · 2021Review
- Article
- Upper Respiratory Tract Microbiome and Otitis Media Intertalk: Lessons from the Literature.Journal of clinical medicine · 2020Review
- Reviewing the Pathogenic Potential of the Otitis-Associated BacteriaFrontiers in cellular and infection microbiology · 2020Review
- Microbial Biodeterioration of Cultural Heritage: Events, Colonization, and Analyses.Microbial ecology · 2019Review
- [Turicella otitidis, contributions to its role in the etiology of ear infections].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018Article
- Genomic evolution of Staphylococcus aureus isolates colonizing the nares and progressing to bacteremia.PloS one · 2018Article
- Characterization of Sinus Microbiota by 16S Sequencing from Swabs.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Article
- Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene.Infectious diseases of poverty · 2016Article
- DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan.BMC microbiology · 2016Article
- Bacteriology of pressure ulcers in individuals with spinal cord injury: What we know and what we should know.The journal of spinal cord medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular-phylogenetic sequence analyses have provided a new perspective on microbial communities by allowing the detection and identification of constituent microorganisms in the absence of cultivation. In this study we used broad-specificity amplification of ribosomal DNA (rDNA) genes to survey organisms present in the human outer ear canal. Samples were obtained from 24 individuals, including members of three extended families, in order to survey the resident microbiota and to examine microbial population structures in individuals related by familial or household associations. To examine the stability of the microbial populations, one individual was sampled four times and another twice over a 14-month period. We found that a distinct set of microbial types was present in the majority of the subjects sampled. The two most prevalent rDNA sequence types that were identified in multiple individuals corresponded closely to those of Alloiococcus otitis and Corynebacterium otitidis, commonly thought to be associated exclusively with infections of the middle ear. Our results suggest, therefore, that the outer ear canal may serve as a reservoir for normally commensal microbes that can contribute to pathogenesis upon introduction into the middle ear. Alternatively, culture analyses of diseases of the middle ear may have been confounded by these contaminating commensal organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.