ArticleJournal of clinical microbiology2003
Genetic diversity of Vibrio cholerae O1 in Argentina and emergence of a new variant.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae.Nature communications · 2020Article
- Revisiting the Global Epidemiology of Cholera in Conjuction With the Genomics ofFrontiers in public health · 2019Review
- Genetic relatedness of selected clinical and environmental non-O1/O139 Vibrio cholerae.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015Article
- Multi-drug resistant toxigenic Vibrio cholerae O1 is persistent in water sources in New Bell-Douala, Cameroon.BMC infectious diseases · 2013Article
- Vibrio cholerae O1 from superficial water of the Tucunduba Stream, Brazilian Amazon.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Vibrio cholerae cytolysin causes an inflammatory response in human intestinal epithelial cells that is modulated by the PrtV protease.PloS one · 2009Article
- Molecular analyses of Vibrio cholerae O1 clinical strains, including new nontoxigenic variants isolated in Mexico during the Cholera epidemic years between 1991 and 2000.Journal of clinical microbiology · 2009Article
- Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Viable but nonculturable Vibrio cholerae O1 in the aquatic environment of Argentina.Applied and environmental microbiology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic diversity of Vibrio cholerae O1 strains from Argentina was estimated by random amplified polymorphic DNA (RAPD) analysis and pulsed-field gel electrophoresis (PFGE). Twenty-nine isolates carrying the virulence genes ctxA, zot, ace, and tcpA appeared to represent a single clone by both typing methods; while 11 strains lacking these virulence genes exhibited several heterogeneous RAPD and PFGE patterns. Among the last group, a set of isolates from the province Tucumán showed a single RAPD pattern and four closely related PFGE profiles. These strains, isolated from patients with diarrhea, did not produce the major V. cholerae O1 virulence determinants, yet cell supernatants of these isolates caused a heat-labile cytotoxic effect on Vero and Y-1 cells and elicited significant variations on the water flux and short-circuit current in human small intestine mounted in an Ussing chamber. All these effects were completely abolished by incubation with a specific antiserum against El Tor hemolysin, suggesting that this virulence factor was responsible for the toxic activity on both the epithelial cells and the small intestine specimens and may hence be involved in the development of diarrhea. We propose "Tucumán variant" as the designation for this new cluster of cholera toxin-negative V. cholerae O1 strains.
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