ArticleJournal of clinical microbiology2003
Identification of Mycobacterium avium genotypes with distinctive traits by combination of IS1245-based restriction fragment length polymorphism and restriction analysis of hsp65.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Global Assessment of Mycobacterium avium subsp.mSystems · 2019Article
- Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation ofInfection and immunity · 2019Article
- Article
- Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection.BMC genomics · 2014Article
- Shared Mycobacterium avium genotypes observed among unlinked clinical and environmental isolates.Applied and environmental microbiology · 2013Article
- Comparison of the (CCG)4-based PCR and MIRU-VNTR for molecular typing of Mycobacterium avium strains.Molecular biology reports · 2012Article
- First description of natural and experimental conjugation between Mycobacteria mediated by a linear plasmid.PloS one · 2012Article
- Article
- Natural occurrence of horizontal transfer of Mycobacterium avium- specific insertion sequence IS1245 to Mycobacterium kansasii.Journal of clinical microbiology · 2010Article
- Avian tuberculosis of zoonotic importance at a zoo on the Bogotá Andean plateau (Sabana), Colombia.The Canadian veterinary journal = La revue veterinaire canadienne · 2009Article
- Mycobacterium avium in the postgenomic era.Clinical microbiology reviews · 2007Review
- New probes used for IS1245 and IS1311 restriction fragment length polymorphism of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis isolates of human and animal origin in Norway.BMC microbiology · 2007Article
- Isolation of the genome sequence strain Mycobacterium avium 104 from multiple patients over a 17-year period.Journal of clinical microbiology · 2006Article
- Whole-genome plasticity among Mycobacterium avium subspecies: insights from comparative genomic hybridizations.Journal of bacteriology · 2006Article
- Distribution of IS1311 and IS1245 in Mycobacterium avium subspecies revisited.Journal of clinical microbiology · 2005Article
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Authors and funding
6 authors.
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Abstract
One-hundred eight Mycobacterium avium isolates from pigs, humans, birds, and bovines were typed by the IS1245-based restriction fragment length polymorphism (RFLP) method and PCR-restriction enzyme analysis (PRA) of hsp65. Nine clusters of isolates showing more than 80% similarity in their RFLP profiles were detected. The largest cluster (cluster B) included 32 of 79 pig isolates (40.5%), 3 of 25 human isolates (12%), and 1 of 2 bovine isolates, comprising 33% of all isolates. The second largest cluster (cluster A) included 18 pig isolates (22.8%) and 6 human isolates (24%). Six smaller clusters included six pig isolates (clusters C and D), four and two human isolates (clusters E and F, respectively), two pig isolates (cluster I), and two pig isolates plus one bovine isolate and the avian purified protein derivative strain (cluster H). Cluster G represented the "bird-type" profile and included the bird isolate in this series, one pig isolate, plus reference strain R13. PRA revealed four allelic variants. Seventy-seven isolates were identified as M. avium PRA variant I, 24 were identified as M. avium PRA variant II, 6 were identified as M. avium PRA variant III, and 1 was identified as M. avium PRA variant IV. Except for three isolates from cluster B, each of the RFLP clusters was associated with a single PRA pattern. Isolates with unique (nonclustered) RFLP profiles were distributed between PRA variants I and II, and there was one unique isolate of PRA variant IV. These observations are consistent with divergent evolution within M. avium, resulting in the emergence of distinct lineages with particular competence to infect animals and humans.
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