ArticleAmerican journal of human genetics2003
Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis.Frontiers in public health · 2022Pooled it
- Race and ethnicity in genetic research.American journal of medical genetics. Part A · 2007Pooled it
- A Genetic Variant inFrontiers in oncology · 2022Article
- Functional Role of AKNA: A Scoping Review.Biomolecules · 2021Article
- Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet's Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Association of Interferon-The American journal of tropical medicine and hygiene · 2017Article
- Properties of STAT1 and IRF1 enhancers and the influence of SNPs.BMC molecular biology · 2017Article
- Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions.Bosnian journal of basic medical sciences · 2016Article
- Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum.The Journal of allergy and clinical immunology · 2015Article
- At the bedside: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer.Journal of leukocyte biology · 2014Review
- Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Host Gene Polymorphisms in Relation to Helicobacter Pylori Infection and Associated Diseases in a Population Based Cohort.Gastroenterology research · 2013Article
- First-degree relatives of early-onset gastric cancer patients show a high risk for gastric cancer: phenotype and genotype profile.Virchows Archiv : an international journal of pathology · 2013Article
- Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.Cell research · 2011Article
- Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4.5 million US male veterans.Cancer · 2011Article
- Concurrent genotyping of Helicobacter pylori virulence genes and human cytokine SNP sites using whole genome amplified DNA derived from minute amounts of gastric biopsy specimen DNA.BMC microbiology · 2008Article
- Enteric infections, diarrhea, and their impact on function and development.The Journal of clinical investigation · 2008Review
- Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice.The American journal of pathology · 2007Article
- Clarithromycin resistance, tumor necrosis factor alpha gene polymorphism and mucosal inflammation affect H. pylori eradication success.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Mannose-binding lectin and maladies of the bowel and liver.World journal of gastroenterology · 2006Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori is considered the most prevalent infectious agent among humans, and it causes gastric inflammation, gastroduodenal ulcers, and a risk of gastric cancer. We performed a genomewide linkage analysis among Senegalese siblings phenotyped for H. pylori-reactive serum immunoglobulin G. A multipoint LOD score of 3.1 was obtained at IFNGR1, the gene that encodes chain 1 of the interferon-gamma (IFN-gamma) receptor. Sequencing of IFNGR1 revealed -56C-->T, H318P, and L450P variants, which were found to be associated with high antibody concentrations. The inclusion of these in the linkage analysis raised the LOD score to 4.2. The variants were more prevalent in Africans than in whites. Our findings indicate that IFN-gamma signaling plays an essential role in human H. pylori infection, and they contribute to an explanation of the observations of high prevalences and relatively low pathogenicity of H. pylori in Africa. Moreover, they provide further support for the value of genomewide linkage studies in the analysis of susceptibility to infection and other complex genetic traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.