ArticleProceedings of the National Academy of Sciences of the United States of America2003
Artificial cells: unique insights into exocytosis using liposomes and lipid nanotubes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Targeted drug delivery systems for cardiovascular disease treatment: principles, targeting strategies, and future prospects.Annals of medicine · 2026Review
- Direct Acquisition of the Gap Height of Biological Tissue-Electronic Chemical Sensor Interfaces.Angewandte Chemie (International ed. in English) · 2022Article
- Cysteine-Encapsulated Liposome for Investigating Biomolecular Interactions at Lipid Membranes.International journal of molecular sciences · 2022Article
- Vesicular release dynamics are altered by the interaction between the chemical cargo and vesicle membrane lipids.Chemical science · 2021Article
- Integrin-Functionalised Giant Unilamellar Vesicles via Gel-Assisted Formation: Good Practices and Pitfalls.International journal of molecular sciences · 2021Article
- Continuous-Flow Production of Liposomes with a Millireactor under Varying Fluidic Conditions.Pharmaceutics · 2020Article
- Mechanical Tension of Biomembranes Can Be Measured by Super Resolution (STED) Microscopy of Force-Induced Nanotubes.Nano letters · 2020Article
- Cell-Inspired All-Aqueous Microfluidics: From Intracellular Liquid-Liquid Phase Separation toward Advanced Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Physicochemical considerations for bottom-up synthetic biology.Emerging topics in life sciences · 2019Article
- Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients.Journal of visualized experiments : JoVE · 2018Article
- Single Synaptic Observation of Cholinergic Neurotransmission on Living Neurons: Concentration and Dynamics.Journal of the American Chemical Society · 2018Article
- Amperometry methods for monitoring vesicular quantal size and regulation of exocytosis release.Pflugers Archiv : European journal of physiology · 2018Review
- 'Full fusion' is not ineluctable during vesicular exocytosis of neurotransmitters by endocrine cells.Proceedings. Mathematical, physical, and engineering sciences · 2017Article
- Cholesterol Alters the Dynamics of Release in Protein Independent Cell Models for Exocytosis.Scientific reports · 2016Article
- Two modes of exocytosis in an artificial cell.Scientific reports · 2014Article
- Article
- Use of β-galactosidase liposome model as a novel method to screen freeze-drying cryoprotectants.World journal of microbiology & biotechnology · 2013Article
- A functioning artificial secretory cell.Scientific reports · 2012Article
- Mechanics of lipid bilayer junctions affecting the size of a connecting lipid nanotube.Nanoscale research letters · 2011Article
- Temporal resolution in electrochemical imaging on single PC12 cells using amperometry and voltammetry at microelectrode arrays.Analytical chemistry · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exocytosis is the fundamental process underlying neuronal communication. This process involves fusion of a small neurotransmitter-containing vesicle with the plasma membrane of a cell to release minute amounts of transmitter molecules. Exocytosis is thought to go through an intermediate step involving formation of a small lipid nanotube or fusion pore, followed by expansion of the pore to the final stage of exocytosis. The process of exocytosis has been studied by various methods; however, when living cells are used it is difficult to discriminate between the molecular effects of membrane proteins relative to the mechanics of lipid-membrane-driven processes and to manipulate system parameters (e.g., membrane composition, pH, ion concentration, temperature, etc.). We describe the use of liposome-lipid nanotube networks to create an artificial cell model that undergoes the later stages of exocytosis. This model shows that membrane mechanics, without protein intervention, can drive expansion of the fusion pore to the final stage of exocytosis and can affect the rate of transmitter release through the fusion pore.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.