ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Gradient steepness influences the pathfinding decisions of neuronal growth cones in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- MACC1-induced migration in tumors: Current state and perspective.Frontiers in oncology · 2023Review
- Characterization of plexinA and two distinct semaphorin1a transcripts in the developing and adult cricket Gryllus bimaculatus.The Journal of comparative neurology · 2020Article
- Neuronal Innervation of the Subgenual Organ Complex and the Tibial Campaniform Sensilla in the Stick Insect Midleg.Insects · 2020Article
- High-throughput three-dimensional chemotactic assays reveal steepness-dependent complexity in neuronal sensation to molecular gradients.Nature communications · 2018Article
- Article
- Microfluidic analysis of extracellular matrix-bFGF crosstalk on primary human myoblast chemoproliferation, chemokinesis, and chemotaxis.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Synergistic effects of 3D ECM and chemogradients on neurite outgrowth and guidance: a simple modeling and microfluidic framework.PloS one · 2014Article
- Chemistry with spatial control using particles and streams().RSC advances · 2012Article
- Gradient biomaterials and their influences on cell migration.Interface focus · 2012Article
- Delivery of chemotropic proteins and improvement of dopaminergic neuron outgrowth through a thixotropic hybrid nano-gel.Journal of materials science. Materials in medicine · 2011Article
- Chemical gradients and chemotropism in yeast.Cold Spring Harbor perspectives in biology · 2009Review
- Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis.PLoS biology · 2009Article
- Spatially patterned gene expression for guided neurite extension.Journal of neuroscience research · 2009Article
- Reverse leukocyte migration can be attractive or repulsive.Trends in cell biology · 2008Review
- Biomolecular gradients in cell culture systems.Lab on a chip · 2008Review
- Bound attractant at the leading vs. the trailing edge determines chemotactic prowess.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Bias in the gradient-sensing response of chemotactic cells.Journal of theoretical biology · 2007Article
- The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis.Genetics · 2007Article
- Distinguishing modes of eukaryotic gradient sensing.Biophysical journal · 2005Article
- Brain-derived neurotrophic factor regulation of retinal growth cone filopodial dynamics is mediated through actin depolymerizing factor/cofilin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gradients of chemotropic molecules are generally thought to be fundamental for the guidance of neuronal growth cones in the developing embryo. Here we show that the grasshopper-secreted semaphorin Sema 2a is expressed in a gradient during the period of tibial Ti1 pioneer axon pathfinding into the CNS. At two critical Ti1 growth cone choice points, the Sema 2a gradient differs in steepness, whereas the absolute concentration is the same. Although Ti1 growth cones enter and extend up both steep and shallow gradients of Sema 2a, fewer projection errors occur along the steep gradient, suggesting that the steepness of the gradient encodes the critical guidance information into the pathfinding growth cone. In contrast, an increase in the absolute concentration of Sema 2a appears to constrain the Ti1 growth cone size. Using these in vivo gradients, we provide evidence that the Ti1 growth cone detects the Sema 2a gradient by measuring the fractional change in Sema 2a concentration, thereby demonstrating one mechanism that neuronal growth cones may use to detect and read gradients in vivo.
Indexed as
Identifiers
12514216PMC6742127What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.