ArticleGenes & development2003
Phosphorylation of histone H3 during transcriptional activation depends on promoter structure.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.Stem cell reports · 2020Article
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- Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders.Journal of biosciences · 2020Review
- ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription.Molecular cell · 2017Article
- Upregulated SMYD3 promotes bladder cancer progression by targeting BCLAF1 and activating autophagy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- 14-3-3 mediates histone cross-talk during transcription elongation in Drosophila.PLoS genetics · 2010Article
- Chromatin insulators specifically associate with different levels of higher-order chromatin organization in Drosophila.Chromosoma · 2010Article
- Article
- Changes in chromatin structure correlate with transcriptional activity of nucleolar rDNA in polytene chromosomes.Chromosoma · 2009Article
- Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy.British journal of pharmacology · 2008Article
- The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization.EMBO reports · 2008Article
- Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila.Genes & development · 2007Article
- Selective repression of low-density lipoprotein receptor expression by SP600125: coupling of histone H3-Ser10 phosphorylation and Sp1 occupancy.Molecular and cellular biology · 2006Article
- Regulation of chromatin structure by histone H3S10 phosphorylation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- Occupancy of the Drosophila hsp70 promoter by a subset of basal transcription factors diminishes upon transcriptional activation.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The homologous Drosophila transcriptional adaptors ADA2a and ADA2b are both required for normal development but have different functions.Molecular and cellular biology · 2005Article
- Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms.The EMBO journal · 2005Article
- The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.Genes & development · 2004Article
- Histone H3.3 is enriched in covalent modifications associated with active chromatin.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Stress-induced transcription of satellite III repeats.The Journal of cell biology · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Covalent modifications of histone N-terminal tails are required for the proper assembly and activation of the general transcription factors at promoters. Here, we analyze histone acetylation and phosphorylation in Drosophila transgenes activated by the yeast Gal4 transcriptional activator in the context of different promoters. We show that, independent of the promoter, transcription does not correlate with acetylation of either H3-Lys 14 or H4-Lys 8. Histone H3 associated with the DNA of Gal4-induced transcribing transgenes driven by the Drosophila Hsp70 promoter is hyperphosphorylated at Ser 10 during transcription. Surprisingly, histone H3 at Gal4-induced transgenes driven by the P element Transposase promoter is not hyperphosphorylated. The data suggest that transcription occurs without acetylated H4 and H3 in both transgenes in Drosophila polytene chromosomes. Instead, phosphorylation of H3 is linked to transcription and can be modulated by the structure of the promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.