ArticleNeurochemical research2002
Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes.
Article in Neurochemical research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Fasudil inhibits α-synuclein aggregation through ROCK-inhibition-mediated mechanisms.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Glial progenitor cells of the adult human white and grey matter are contextually distinct.Glia · 2023Article
- Polarized Distribution of Active Myosin II Regulates Directional Migration of Cultured Olfactory Ensheathing Cells.Scientific reports · 2017Article
- Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro.Neurobiology of aging · 2012Article
- Intrinsic migratory properties of cultured Schwann cells based on single-cell migration assay.PloS one · 2012Article
- Cytotoxic Effects on HL-60 Cells of Myosin Light Chain Kinase Inhibitor ML-7 Alone and in Combination with Flavonoids.Toxicological research · 2009Article
- Polarity development in oligodendrocytes: sorting and trafficking of myelin components.Journal of molecular neuroscience : MN · 2008Review
- Myosin IIA is required for cytolytic granule exocytosis in human NK cells.The Journal of experimental medicine · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligodendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.
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Registered trials
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