ReviewNeurochemical research2002
The structure and function of myelin: from inert membrane to perfusion pump.
Review in Neurochemical research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- A novel myelin basic protein transcript variant in the murine central nervous system.Molecular biology reports · 2019Article
- Estrogen receptors and estetrol-dependent neuroprotective actions: a pilot study.The Journal of endocrinology · 2017Article
- Time-Dependent Progression of Demyelination and Axonal Pathology in MP4-Induced Experimental Autoimmune Encephalomyelitis.PloS one · 2015Article
- Altered interhemispheric and temporal lobe white matter microstructural organization in severe chronic schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- How histone deacetylases control myelination.Molecular neurobiology · 2011Review
- Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans.PLoS genetics · 2011Article
- Article
- Magnetic resonance imaging of myelin.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007Review
- White matter rafting--membrane microdomains in myelin.Neurochemical research · 2007Review
- Expression profiling reveals multiple myelin alterations in murine succinate semialdehyde dehydrogenase deficiency.Journal of inherited metabolic disease · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this overview is to propose a novel structure/function model of central nervous system myelin. Although myelin is known to be a compact multilamellar structure that wraps around axons, the biologic role this structure plays in the nervous system remains an enigma. One means of ascertaining myelin's biologic role is by analyzing its structure. The recent discovery of tight junctions in myelin may be the key that unlocks the mysterious black box of myelin structure/function. Tight junctions in other cell types are invariably adjacent to adherens junctions, with both of these junctional plaques playing critical roles in paracellular barrier function, i.e., adhesion of cell membranes, signal transduction, and fluid movement between cells via aqueous pores and channels. The application of current knowledge about junctional plaques to myelin is an original concept. This knowledge, taken together with evidence from studies of normal and pathologic myelin, supports the possibility that a primary function of junctional plaques in myelin is to perfuse the periaxonal space.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.