ArticleProceedings of the National Academy of Sciences of the United States of America2003
Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
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Who cites it
147 citing papers in PubMed, 525 citations in OpenAlex.
- Rhizobacteria promote plant growth via secretion of N-(3-oxooctanoyl)-L-homoserine lactone.Horticulture research · 2026Article
- A Journey into Plant-Microbe Interactions: From Lab to Field for a Sustainable Agriculture.Advances in experimental medicine and biology · 2026Review
- Mechanisms of Microorganisms Alleviating Drought and Salt Stresses in Plants.Microorganisms · 2025Review
- First Evidence of Metabolically Active Intracellular Bacteria inJournal of agricultural and food chemistry · 2025Article
- Harnessing Seed Endophytic Microbiomes: A Hidden Treasure for Enhancing Sustainable Agriculture.Plants (Basel, Switzerland) · 2025Review
- Quorum Signaling Molecules: Interactions Between Plants and Associated Pathogens.International journal of molecular sciences · 2025Review
- Understanding MeJA induced-resistance toFrontiers in plant science · 2025Article
- The plant growth-promotingFrontiers in microbiology · 2025Article
- Quorum sensing in biofilm-mediated heavy metal resistance and transformation: environmental perspectives and bioremediation.Frontiers in microbiology · 2025Review
- Role of bacterial quorum sensing in plant growth promotion.World journal of microbiology & biotechnology · 2024Review
- Targeting quorum sensing for manipulation of commensal microbiota.BMC biotechnology · 2024Review
- Bacterial N-Acyl Homoserine Lactone Priming Enhances Leaf-Rust Resistance in Winter Wheat and Some Genomic Regions Are Associated with Priming Efficiency.Microorganisms · 2024Article
- Quorum Sensing Inhibitors: An Alternative Strategy to Win the Battle against Multidrug-Resistant (MDR) Bacteria.Molecules (Basel, Switzerland) · 2024Review
- Quorum sensing-related activities of beneficial and pathogenic bacteria have important implications for plant and human health.FEMS microbiology ecology · 2024Review
- Synthetic microbe-to-plant communication channels.Nature communications · 2024Article
- Combination of bacterial N-acyl homoserine lactones primes Arabidopsis defenses via jasmonate metabolism.Plant physiology · 2023Article
- Quorum sensing gene regulation inFrontiers in microbiology · 2023Article
- Review
- AHL-Priming Protein 1 mediates N-3-oxo-tetradecanoyl-homoserine lactone priming in Arabidopsis.BMC biology · 2022Article
- Wild Wheat Rhizosphere-Associated Plant Growth-Promoting Bacteria Exudates: Effect on Root Development in Modern Wheat and Composition.International journal of molecular sciences · 2022Article
87 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many bacteria use N-acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated "quorum-sensing" regulation. We have used proteome analysis to show that a eukaryotic host, the model legume Medicago truncatula, is able to detect nanomolar to micromolar concentrations of bacterial AHLs from both symbiotic (Sinorhizobium meliloti) and pathogenic (Pseudomonas aeruginosa) bacteria, and that it responds in a global manner by significant changes in the accumulation of over 150 proteins, 99 of which have been identified by peptide mass fingerprinting. The accumulation of specific proteins and isoforms depended on AHL structure, concentration, and time of exposure. AHLs were also found to induce tissue-specific activation of beta-glucuronidase (GUS) reporter fusions to an auxin-responsive and three chalcone synthase promoters, consistent with AHL-induced changes in the accumulation of auxin-responsive and flavonoid synthesis proteins. In addition, exposure to AHLs was found to induce changes in the secretion of compounds by the plants that mimic quorum-sensing signals and thus have the potential to disrupt quorum sensing in associated bacteria. Our results indicate that eukaryotes have an extensive range of functional responses to AHLs that may play important roles in the beneficial or pathogenic outcomes of eukaryote-prokaryote interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.