ArticleThe Plant cell2003
Oxidative remodeling of chromoplast carotenoids: identification of the carotenoid dioxygenase CsCCD and CsZCD genes involved in Crocus secondary metabolite biogenesis.
Article in The Plant cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 309 citations in OpenAlex.
- Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy.Nutrients · 2019Trial
- Rainfall and minimum temperature modulate the expression of CsβCH and CsCCD1 genes in saffron stigma and improve its quality: comparison of traditional, non-traditional and indoor sites.Molecular biology reports · 2026Article
- The carotenoids metabolism during tomato fruit ripening: insights into multi-level regulatory network.BMC plant biology · 2026Review
- Temporal gene expression profiling suggests stage-specific regulation of apocarotenoid biosynthesis genes during stigma development inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Transcriptomic and metabolomic analysis of carotenoid metabolism and accumulation of carotenoid-derived products in tobacco leaves before and after curing.Frontiers in plant science · 2025Article
- Carotenoid Cleavage Dioxygenase GeneInternational journal of molecular sciences · 2024Article
- Co-regulatory network analysis of the main secondary metabolite (SM) biosynthesis in Crocus sativus L.Scientific reports · 2024Article
- Genome-wide identification and in-silico expression analysis of CCO gene family in sunflower (Helianthus annnus) against abiotic stress.Plant molecular biology · 2024Article
- Research Progress in Heterologous Crocin Production.Marine drugs · 2023Review
- The Functional Characteristics and Soluble Expression of SaffronInternational journal of molecular sciences · 2023Article
- Dynamics of annatto pigment synthesis and accumulation in seeds of Bixa orellana L. revealed by integrated chemical, anatomical, and RNA-Seq analyses.Protoplasma · 2023Article
- Characterization ofPlants (Basel, Switzerland) · 2023Article
- Efficacy of Hydroponically Cultivated Saffron in the Preservation of Retinal Pigment Epithelium.Molecules (Basel, Switzerland) · 2023Article
- Mapping and Validation ofInternational journal of molecular sciences · 2022Article
- The role of photosynthesis related pigments in light harvesting, photoprotection and enhancement of photosynthetic yield in planta.Photosynthesis research · 2022Review
- The Pharmacological Activities ofOxidative medicine and cellular longevity · 2022Review
- Genome-wide characterization of carotenoid oxygenase gene family in three cotton species and functional identification of GaNCED3 in drought and salt stress.Journal of applied genetics · 2021Article
- Crocus transcription factors CstMYB1 and CstMYB1R2 modulate apocarotenoid metabolism by regulating carotenogenic genes.Plant molecular biology · 2021Article
- Carotenoid cleavage dioxygenases (HD-CCD1A and B) contribute as strong negative regulators of β-carotene in Indian bread wheat (cv. HD2967).3 Biotech · 2021Article
- Molecular components affecting ocular carotenoid and retinoid homeostasis.Progress in retinal and eye research · 2021Review
29 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accumulation of three major carotenoid derivatives-crocetin glycosides, picrocrocin, and safranal-is in large part responsible for the color, bitter taste, and aroma of saffron, which is obtained from the dried styles of Crocus. We have identified and functionally characterized the Crocus zeaxanthin 7,8(7',8')-cleavage dioxygenase gene (CsZCD), which codes for a chromoplast enzyme that initiates the biogenesis of these derivatives. The Crocus carotenoid 9,10(9',10')-cleavage dioxygenase gene (CsCCD) also has been cloned, and the comparison of substrate specificities between these two enzymes has shown that the CsCCD enzyme acts on a broader range of precursors. CsZCD expression is restricted to the style branch tissues and is enhanced under dehydration stress, whereas CsCCD is expressed constitutively in flower and leaf tissues irrespective of dehydration stress. Electron microscopy revealed that the accumulation of saffron metabolites is accompanied by the differentiation of amyloplasts and chromoplasts and by interactions between chromoplasts and the vacuole. Our data suggest that a stepwise sequence exists that involves the oxidative cleavage of zeaxanthin in chromoplasts followed by the sequestration of modified water-soluble derivatives into the central vacuole.
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