ArticleProceedings of the National Academy of Sciences of the United States of America2003
Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- A Duality of Function: An Integrative Model of RACK1 as a Switch Between Translational and Signaling Hubs.International journal of molecular sciences · 2025Review
- The roles of RACK1 in the pathogenesis of Alzheimer's disease.Journal of biomedical research · 2024Article
- Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis).Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2021Article
- Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction.Neurobiology of stress · 2020Article
- Cholinergic Stress Signals Accompany MicroRNA-Associated Stereotypic Behavior and Glutamatergic Neuromodulation in the Prefrontal Cortex.Biomolecules · 2020Article
- Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy.International journal of ophthalmology · 2020Article
- Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.Molecular neurobiology · 2019Article
- Obesity-related acetylcholinesterase elevation is reversed following laparoscopic sleeve gastrectomy.International journal of obesity (2005) · 2019Article
- Expression of acetylcholinesterase 1 is associated with brood rearing status in the honey bee, Apis mellifera.Scientific reports · 2017Article
- A novel missense variant in PRKCB segregates low-frequency hearing loss in an autosomal dominant family with Meniere's disease.Human molecular genetics · 2016Article
- Role of acetylcholinesterase in lung cancer.Thoracic cancer · 2015Review
- AChE and RACK1 promote the anti-inflammatory properties of fluoxetine.Journal of molecular neuroscience : MN · 2014Article
- Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease.Journal of molecular neuroscience : MN · 2014Review
- AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro.Environmental health perspectives · 2013Article
- RACK1 is involved in endothelial barrier regulation via its two novel interacting partners.Cell communication and signaling : CCS · 2013Article
- Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1.PloS one · 2012Article
- Article
- RACK1, A multifaceted scaffolding protein: Structure and function.Cell communication and signaling : CCS · 2011Article
- ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors.Molecular pharmacology · 2010Article
- Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression.Molecular psychiatry · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behavioral reactions to stress are altered in numerous psychiatric and neurodegenerative syndromes, but the corresponding molecular processes and signal transduction pathways are yet unknown. Here, we report that, in mice, the stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein kinase CbetaII (PKCbetaII), which is known to be involved in fear conditioning. In stress-responsive brain regions of normal FVBN mice, the mild stress of i.p. injection increased AChE and PKCbetaII levels in a manner suppressible by antisense prevention of AChE-R accumulation. Injection stress also prolonged conflict between escape and hiding in the emergence into an open field test. Moreover, transgenic FVBN mice overexpressing AChE-R displayed prolonged delay to emerge into another field (fear-induced behavioral inhibition), associated with chronically intensified neuronal colabeling of RACK1 and PKCbetaII in stress-responsive brain regions. These findings are consistent with the hypothesis that stress-associated changes in cholinergic gene expression regulate neuronal PKCbetaII functioning, promoting fear-induced conflict behavior after stress.
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