ArticleMolecular and cellular biology2003
p21(CIP1) Controls proliferating cell nuclear antigen level in adult cardiomyocytes.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development.Cell death and differentiation · 2026Article
- The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.Communications biology · 2026Article
- Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure.International journal of molecular sciences · 2021Review
- Impact of PCSK9 on CTRP9-Induced Metabolic Effects in Adult Rat Cardiomyocytes.Frontiers in physiology · 2021Article
- Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair.Cell research · 2017Article
- Understanding cardiomyocyte proliferation: an insight into cell cycle activity.Cellular and molecular life sciences : CMLS · 2017Review
- Antitumor effect of forbesione isolated fromOncology letters · 2016Article
- GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient induced pluripotent stem cell model.Annals of neurology · 2016Article
- Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window.Science translational medicine · 2015Article
- Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression.Cell cycle (Georgetown, Tex.) · 2015Article
- REGγ is a strong candidate for the regulation of cell cycle, proliferation and the invasion by poorly differentiated thyroid carcinoma cells.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes.The Journal of biological chemistry · 2011Article
- Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.Annals of botany · 2011Review
- Knockdown of cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle.The Journal of biological chemistry · 2011Article
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- Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2.The Journal of biological chemistry · 2009Article
- hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.Oncogene · 2008Article
- Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice.Transgenic research · 2008Article
- Nox2 regulates endothelial cell cycle arrest and apoptosis via p21cip1 and p53.Free radical biology & medicine · 2007Article
- FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Cell cycle withdrawal associated with terminal differentiation is responsible for the incapability of many organs to regenerate after injury. Here, we employed a cell-free system to analyze the molecular mechanisms underlying cell cycle arrest in cardiomyocytes. In this assay, incubation of S phase nuclei mixed with cytoplasmic extract of S phase cells and adult primary cardiomyocytes results in a dramatic reduction of proliferating cell nuclear antigen (PCNA) protein levels. This effect was blocked by the proteasome inhibitors MG132 and lactacystin, whereas actinomycin D and cycloheximide had no effect. Immunodepletion and addback experiments revealed that the effect of cardiomyocyte extract on PCNA protein levels is maintained by p21 but not p27. In serum-stimulated cardiomyocytes PCNA expression was reconstituted, whereas the protein level of p21 but not that of p27 was reduced. Cytoplasmic extract of serum-stimulated cardiomyocytes did not influence the PCNA protein level in S phase nuclei. Moreover, the hypertrophic effect of serum stimulation was blocked by ectopic expression of p21 and the PCNA protein level was found to be upregulated in adult cardiomyocytes derived from p21 knockout mice. Our data provide evidence that p21 regulates the PCNA protein level in adult cardiomyocytes, which has implications for cardiomyocyte growth control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.