ArticleMolecular and cellular biology2003
Mcm1p-induced DNA bending regulates the formation of ternary transcription factor complexes.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Haploinsufficiency of the sex-determining genes atiScience · 2022Article
- Direct Single-Molecule Observation of Sequential DNA Bending Transitions by the Sox2 HMG Box.International journal of molecular sciences · 2018Article
- Investigation of protein secretion and secretion stress in Ashbya gossypii.BMC genomics · 2014Article
- Cell cycle-regulated transcription: effectively using a genomics toolbox.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Contribution of transcription factor binding site motif variants to condition-specific gene expression patterns in budding yeast.PloS one · 2012Article
- Molecular interactions and protein-induced DNA hairpin in the transcriptional control of bacteriophage ø29 DNA.International journal of molecular sciences · 2010Review
- MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain.Molecular and cellular biology · 2006Article
- Flexible promoter architecture requirements for coactivator recruitment.BMC molecular biology · 2006Article
- From genomes to systems: the path with yeast.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Dynamic modeling of cis-regulatory circuits and gene expression prediction via cross-gene identification.BMC bioinformatics · 2005Article
- Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.Applied and environmental microbiology · 2005Article
- A precise DNA bend angle is essential for the function of the phage phi29 transcriptional regulator.Nucleic acids research · 2005Article
- Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Alpha1-induced DNA bending is required for transcriptional activation by the Mcm1-alpha1 complex.Nucleic acids research · 2004Article
- Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB.Molecular and cellular biology · 2003Article
- Molecular determinants of the cell-cycle regulated Mcm1p-Fkh2p transcription factor complex.Nucleic acids research · 2003Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yeast MADS-box transcription factor Mcm1p plays an important regulatory role in several diverse cellular processes. In common with a subset of other MADS-box transcription factors, Mcm1p elicits substantial DNA bending. However, the role of protein-induced bending by MADS-box proteins in eukaryotic gene regulation is not understood. Here, we demonstrate an important role for Mcm1p-mediated DNA bending in determining local promoter architecture and permitting the formation of ternary transcription factor complexes. We constructed mutant mcm1 alleles that are defective in protein-induced bending. Defects in nuclear division, cell growth or viability, transcription, and gene expression were observed in these mutants. We identified one likely cause of the cell growth defects as the aberrant formation of the cell cycle-regulatory Fkh2p-Mcm1p complex. Microarray analysis confirmed the importance of Mcm1p-mediated DNA bending in maintaining correct gene expression profiles and revealed defects in Mcm1p-mediated repression of Ty elements and in the expression of the cell cycle-regulated YFR and CHS1 genes. Thus, we discovered an important role for DNA bending by MADS-box proteins in the formation and function of eukaryotic transcription factor complexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.