ArticleWorld journal of gastroenterology2003
K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- K-ras mutational status in cytohistological tissue as a molecular marker for the diagnosis of pancreatic cancer: a systematic review and meta-analysis.Disease markers · 2014Pooled it
- Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients.European journal of epidemiology · 2011Article
- Loss of heterozygosity of Kras2 gene on 12p12-13 in Chinese colon carcinoma patients.World journal of gastroenterology · 2006Article
- Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro.World journal of gastroenterology · 2004Article
- Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer.World journal of gastroenterology · 2004Article
- Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC.World journal of gastroenterology · 2003Article
- Relationship between nuclear morphometry, DNA content and resectability of pancreatic cancer.World journal of gastroenterology · 2003Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the utility of K-ras mutation analysis of ultrasound guided fine-needle aspirate biopsy of pancreatic masses.
methodsSixty-six ultrasound guided fine-needle biopsies were evaluated by cytology, histology and k-ras mutation. The mutation at codon 12 of the k-ras oncogene was detected by artificial restriction fragment length polymorphisms using Bst NI approach.
resultsThe presence of malignant cells was reported in 40 of 54 pancreatic carcinomas and K-ras mutations were detected in 45 of the 54 FNABs of pancreatic carcinomas. The sensitivity of cytology and k-ras mutation were 74 % and 83 %, respectively. The specialty of cytology and k-ras mutation were both 100 %. The sensitivity and specialty of k-ras mutation combined with cytology were 83 % and 100 %, respectively.
conclusionHigh diagnostic accuracy with acceptable discomfort of FNAB make it useful in diagnosis of pancreatic carcinoma. Ultrasound guided fine-needle biopsy is a safe and feasible method for diagnosing pancreatic cancer. Pancreatic carcinoma has the highest K-ras mutation rate among all solid tumors. The mutation rate of k-ras is about 80-100 %. The usage of mutation of codon 12 of k-ras oncogene combined with cytology is a good alternative for evaluation of pancreatic masses.
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