ArticleWorld journal of gastroenterology2003
Effect of oxytocin on contraction of rabbit proximal colon in vitro.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Prolactin and oxytocin as modulators of intestinal contractility and glucose uptake.Frontiers in physiology · 2026Article
- Oxytocin/Oxytocin Receptor Signalling in the Gastrointestinal System: Mechanisms and Therapeutic Potential.International journal of molecular sciences · 2024Review
- Mechanism of Oxytocin-Induced Contraction in Rat Gastric Circular Smooth Muscle.International journal of molecular sciences · 2022Article
- Inhibitory effect of the Kampo medicinal formula Yokukansan on acute stress-induced defecation in rats.Neuropsychiatric disease and treatment · 2018Article
- Gender-related differences in irritable bowel syndrome: potential mechanisms of sex hormones.World journal of gastroenterology · 2014Review
- Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms.BMC gastroenterology · 2009Article
- Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human hepatoma BEL-7402 cells.World journal of gastroenterology · 2003Article
- Effects of neurotrophins on gastrointestinal myoelectric activities of rats.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of oxytocin (OT) on isolated rabbit proximal colon and its mechanism.
methodsBoth longitudinal muscle (LM) and circular muscle (CM) were suspended in a tissue chamber containing 5 mL Krebs solution (37 degrees ), bubbled continuously with 950 mL x L(-1) O(2) and 50 mL x L(-1) CO(2). Isometric spontaneous contractile responses to oxytocin or other drugs were recorded in circular and longitudinal muscle strips.
resultsOT (0.1 U x L(-1)) failed to elicit significant effects on the contractile activity of proximal colonic smooth muscle strips (P>0.05). OT (1 to 10 U x L(-1)) decreased the mean contractile amplitude and the contractile frequency of CM and LM. Hexamethonium (10 micromol x L(-1)) partly blocked the inhibition of oxytocin (1 U x L(-1)) on the contractile frenquency of CM. N(omega))-nitro-L-arginine-methylester (L-NAME, 1 micromol x L (-1)), progesterone (32 micromol x L(-1)) and estrogen (2.6 micromol x L(-1)) had no effects on OT-induced responses.
conclusionOT inhibits the motility of proximal colon in rabbits. The action is partly relevant with N receptor, but irrelevant with that of NO, progesterone or estrogen.
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