ArticleWorld journal of gastroenterology2003
Gene expression profiles at different stages of human esophageal squamous cell carcinoma.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Molecular mechanism detection of stage I to stage II transition of esophageal squamous cell carcinoma: a system biology approach.Gastroenterology and hepatology from bed to bench · 2024Article
- New insights into KLFs and SOXs in cancer pathogenesis, stemness, and therapy.Seminars in cancer biology · 2023Review
- Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1.Cell death & disease · 2023Article
- Interleukin 13 participates in terminal differentiation of esophageal squamous cell carcinoma cells.Journal of gastrointestinal oncology · 2022Article
- Detection of circulating BMP5 as a risk factor for Barrett's esophagus.Scientific reports · 2020Article
- Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma.Oncogene · 2018Article
- ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma.Scientific reports · 2018Article
- DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks.Frontiers in physiology · 2018Article
- Genetic variants in RhoA and ROCK1 genes are associated with the development, progression and prognosis of prostate cancer.Oncotarget · 2017Article
- Future directions in esophageal cancer therapy.Annals of cardiothoracic surgery · 2017Article
- Integrated network analysis and logistic regression modeling identify stage-specific genes in Oral Squamous Cell Carcinoma.BMC medical genomics · 2015Article
- Undervalued criteria in the evaluation of multimodal trials for upper GI cancers.Cancer investigation · 2014Review
- Squamous dysplasia--the precursor lesion for esophageal squamous cell carcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.Current molecular medicine · 2013Article
- Analysis of XPD genetic polymorphisms of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China.Molecular biology reports · 2012Article
- Rho kinase proteins--pleiotropic modulators of cell survival and apoptosis.Anticancer research · 2011Review
- Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance.The Journal of clinical investigation · 2011Article
- Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells.Molecular cancer · 2011Article
- Pharmacological inhibition of Rho-kinase (ROCK) signaling enhances cisplatin resistance in neuroblastoma cells.International journal of oncology · 2010Article
- Immunologic function of dendritic cells in esophageal cancer.Digestive diseases and sciences · 2008Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo characterize the gene expression profiles in different stages of carcinogenesis of esophageal epithelium.
methodsA microarray containing 588 cancer related genes was employed to study the gene expression profile at different stages of esophageal squamous cell carcinoma including basal cell hyperplasia, high-grade dysplasia, carcinoma in situ, early and late cancer. Principle component analysis was performed to search the genes which were important in carcinogenesis.
resultsMore than 100 genes were up or down regulated in esophageal epithelial cells during the stages of basal cell hyperplasia, high-grade dysplasia, carcinoma in situ, early and late cancer. Principle component analysis identified a set of genes which may play important roles in the tumor development. Comparison of expression profiles between these stages showed that some genes, such as P160ROCK, JNK2, were activated and may play an important role in early stages of carcinogenesis.
conclusionThese findings provided an esophageal cancer-specific and stage-specific expression profiles, showing that complex alterations of gene expression underlie the development of malignant phenotype of esophageal cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.