ArticleThe American journal of pathology2003
Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 97 citations in OpenAlex.
- Astrocyte and oligodendrocyte pathology in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson's disease.Frontiers in neurology · 2025Article
- Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB Accumulation.International journal of molecular sciences · 2023Article
- Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy.Frontiers in neuroscience · 2023Review
- Spread of pathological human Tau from neurons to oligodendrocytes and loss of high-firing pyramidal neurons in aging mice.Cell reports · 2022Article
- Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer's Disease and Related Dementias.Cells · 2022Review
- All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer's disease.Frontiers in cellular neuroscience · 2022Review
- Oligodendrogenesis increases in hippocampal grey and white matter prior to locomotor or memory impairment in an adult mouse model of tauopathy.The European journal of neuroscience · 2021Article
- Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies.International journal of molecular sciences · 2021Review
- Cellular and pathological heterogeneity of primary tauopathies.Molecular neurodegeneration · 2021Review
- A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy.Molecular neurodegeneration · 2021Article
- An Overview of Astrocyte Responses in Genetically Induced Alzheimer's Disease Mouse Models.Cells · 2020Review
- Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy.Acta neuropathologica · 2020Article
- Cellular Biology of Tau Diversity and Pathogenic Conformers.Frontiers in neurology · 2020Review
- Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice.Frontiers in neurology · 2020Article
- Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers.Neurobiology of aging · 2019Article
- Targeting Autophagy for the Treatment of Alzheimer's Disease: Challenges and Opportunities.Frontiers in molecular neuroscience · 2019Article
- Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies.Frontiers in aging neuroscience · 2019Article
- Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions.Acta neuropathologica communications · 2017Article
- Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.Neuroscience · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We recently reported a transgenic mouse line (JNPL3) that expresses mutant (P301L) tau and develops neurofibrillary tangles composed of filamentous tau aggregates. Here we show that these mice have abnormal tau filaments not only in neurons, but also in oligodendrocytes and astrocytes. Similar results were detected in another transgenic line (JNPL2+3+) that expresses the longest human tau isoform with the P301L mutation. The ultrastructure of the tau filaments and immunoreactivity with tau and ubiquitin antibodies were similar in glia and neurons. Given similarities of the lesions in the mice to human neuronal and glial inclusions, these transgenic mice appear to be a valuable model to study pathogenesis of the neurodegenerative tauopathies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.