ArticleThe American journal of pathology2003
Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 106 citations in OpenAlex.
- Clinical characteristics of duodenal-type follicular lymphoma.Discover oncology · 2025Review
- Duodenal-type follicular lymphoma inAmerican journal of nuclear medicine and molecular imaging · 2023Article
- Duodenal-type follicular lymphoma more than 10 years after treatment intervention: A retrospective single-center analysis.World journal of gastrointestinal oncology · 2022Article
- Primary follicular lymphoma of the duodenum: a case report and review of literatures.Gastroenterology and hepatology from bed to bench · 2021Article
- Ontogeny, Genetics, Molecular Biology, and Classification of B- and T-Cell Non-Hodgkin Lymphoma.Hematology/oncology clinics of North America · 2019Review
- Radiation Therapy Outcome and Clinical Features of Duodenal-Type Follicular Lymphoma.Cancer research and treatment · 2019Article
- Colorectal follicular lymphoma: A case report.Medicine · 2019Article
- Primary small bowel lymphoma presenting as invagination.Turkish journal of surgery · 2018Article
- t(14;18)-positive B cells: is it seed or soil?Blood · 2018Article
- Gastric follicular lymphoma: A report of 3 cases and a review of the literature.Oncology letters · 2018Article
- CD38 expression on paraffin sections distinguishes follicular lymphoma from reactive follicular hyperplasia.International journal of clinical and experimental pathology · 2018Article
- Anti-leukemic activity of microRNA-26a in a chronic lymphocytic leukemia mouse model.Oncogene · 2017Article
- Primary duodenal follicular lymphoma with late disseminated nodal relapse responsive to rituximab monotherapy: A case report.Molecular and clinical oncology · 2017Article
- Gastrointestinal follicular lymphoma: using primary site as a predictor of survival.Cancer medicine · 2016Article
- Primary Follicular Lymphoma of the Gastrointestinal Tract: Case Report and Review.Journal of gastrointestinal cancer · 2016Review
- Radiation therapy for localized duodenal low-grade follicular lymphoma.Journal of radiation research · 2016Article
- Early lymphoid lesions: conceptual, diagnostic and clinical challenges.Haematologica · 2014Review
- Nature and importance of follicular lymphoma precursors.Haematologica · 2014Review
- Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis.Cancer science · 2014Article
- Early lesions of follicular lymphoma: a genetic perspective.Haematologica · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary follicular lymphoma of the gastrointestinal tract (GI-FL) is a rare so far poorly studied entity. We analyzed four FL cases located in the small intestine and duodenum to gain insight in their pathogenesis and to find an explanation for their low tendency to disseminate outside the GI tract. GI-FLs resemble nodal FLs with respect to morphology and expression of typical GC markers such as CD10, CD38, and BCL-6. We established that the high levels of the anti-apoptosis protein BCL-2 in the tumor cells are in all cases due to a t(14;18) involving the immunoglobulin heavy chain and BCL-2 loci. Detailed immunoglobulin gene analyses on microdissected tissue samples further supported the GC-cell derivation: GI-FLs carry extensively mutated variable heavy-chain genes. The mutation patterns indicated that at some time point in development stringent antigen receptor-based selection processes must have occurred. Interestingly, three of four neoplasms expressed surface IgA, an immunoglobulin class typical of the mucosal immune system and seldom found in nodal FL. In contrast to nodal FLs, the GI-FLs expressed the alpha4beta7 integrin, an established mucosa-homing receptor also expressed by normal intestinal B and T lymphocytes and by low-grade mucosa-associated lymphoid tissue lymphomas. However, the chemokine receptor CXCR3, expressed on low-grade mucosa-associated lymphoid tissue lymphomas, was not detected on the GI-FLs or on nodal FLs. The combined data suggests that primary FL of the small intestine is a distinct entity that originates from local antigen-responsive B cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.