Evidence map›Paper›PMID 12507889›Full record

ArticleThe American journal of pathology2003

Regulation of macrophage migration inhibitory factor expression by glucocorticoids in vivo.

Gunter Fingerle-Rowson, Peter Koch, Rachel Bikoff, Xinchun Lin, Christine N Metz, Firdaus S Dhabhar, Andreas Meinhardt, Richard Bucala

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 131 citations in OpenAlex.

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  19. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Gunter Fingerle-RowsonPicower Institute for Medical Research, Manhasset, New York, USA. g.fingerle-rowson@gmx.de
Peter Koch
Rachel Bikoff
Xinchun Lin
Christine N Metz
Firdaus S Dhabhar
Andreas Meinhardt
Richard Bucala
University of Giessen · DELudwig-Maximilians-Universität München · DEThe Ohio State University · USYale University · US

Funding

Stress &Enhancement of Skin Immunity: Molecular MechaniR01AI048995 · NIAID · OHIO STATE UNIVERSITY · PI QUAN, NING · 2001 to 2004
$1.2M
NIAID NIH HHS AI 48995NIAID NIH HHS R01 AI048995PHS HHS R049610
6 · The paper itself

Abstract

Glucocorticoid hormones are important anti-inflammatory agents because of their anti-inflammatory and proapoptotic action within the immune system. Their clinical usefulness remains limited however by side effects that result in part from their growth inhibitory action on sensitive target tissues. The protein mediator, macrophage migration inhibitory factor (MIF), is an important regulator of the host immune response and exhibits both glucocorticoid-antagonistic and growth-regulatory properties. MIF has been shown to contribute significantly to the development of immunopathology in several models of inflammatory disease. Although there is emerging evidence for a functional interaction between MIF and glucocorticoids in vitro, little is known about their reciprocal influence in vivo. We investigated the expression of MIF in rat tissues after ablation of the hypothalamic-pituitary-adrenal axis and after high-dose glucocorticoid administration. MIF expression is constitutive and independent of the influence of adrenal hormones. Hypophysectomy and the attendent loss of pituitary hormones, by contrast, decreased MIF protein content in the adrenal gland. Administration of dexamethasone was found to increase MIF protein expression in those organs that are considered to be sensitive to the growth inhibitory effects of glucocorticoids (immune and endocrine tissues, skin, and muscle). This increase was most likely because of a posttranscriptional regulatory effect because tissue MIF mRNA levels were not influenced by dexamethasone treatment. Finally, MIF immunoneutralization enhanced lymphocyte egress from blood during stress-induced lymphocyte redistribution, consistent with a functional interaction between MIF and glucocorticoids on immune cell trafficking in vivo. These findings suggest a role for MIF in both the homeostatic and physiological action of glucocorticoids in vivo.

Indexed as

AdrenalectomyAdrenal GlandsAnimalsAntibodies, MonoclonalEpididymisGene ExpressionGlucocorticoidsHypophysectomyHypothalamo-Hypophyseal SystemLeukocytesMacrophage Migration-Inhibitory FactorsMaleMusclesOrgan SpecificityPituitary-Adrenal SystemRatsAntibodies, MonoclonalGlucocorticoidsMacrophage Migration-Inhibitory FactorsRNA, Messenger

Identifiers

PMID12507889
PMCPMC1851131
OpenAlexW2127356442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.