ArticleProceedings of the National Academy of Sciences of the United States of America2003
Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Insights into the mechanism underlying feather pattern formation of sex-linked barring in Chinese native chickens.Poultry science · 2026Article
- Review
- Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour.Cellular oncology (Dordrecht, Netherlands) · 2024Article
- Comprehensive expression analysis for the core cell cycle regulators in the chicken embryo reveals novel tissue-specific synexpression groups and similarities and differences with expression in mouse, frog and zebrafish.Journal of anatomy · 2022Article
- Article
- Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka.Pigment cell & melanoma research · 2019Article
- Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?Stem cells translational medicine · 2018Review
- The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A.PLoS genetics · 2017Article
- EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21.Open biology · 2016Article
- The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration.eLife · 2015Article
- INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.British journal of haematology · 2014Article
- FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21.Cell cycle (Georgetown, Tex.) · 2013Article
- Tumor suppressors: enhancers or suppressors of regeneration?Development (Cambridge, England) · 2013Article
- Genome-wide differential gene expression in immortalized DF-1 chicken embryo fibroblast cell line.BMC genomics · 2011Article
- Detection of functional overlapping genes: simulation and case studies.Journal of molecular evolution · 2010Article
- Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle.Cell stem cell · 2010Article
- Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs.BMC veterinary research · 2009Article
- Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.Cancer cell · 2008Article
- Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53.Oncogene · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The INK4b-ARF-INK4a locus on human chromosome 9p21 (Human Genome Organization designation CDKN2B-CDKN2A), and the corresponding locus on mouse chromosome 4, encodes three distinct products: two members of the INK4 cyclin-dependent kinase inhibitor family and a completely unrelated protein, ARF, whose carboxyl-terminal half is specified by the second exon of INK4a but in an alternative reading frame. As INK4 proteins block the phosphorylation of the retinoblastoma gene product and ARF protects p53 from degradation, the locus plays a key role in tumor suppression and the control of cell proliferation. To gain further insights into the relative importance of INK4a and ARF in different settings, we have isolated and characterized the equivalent locus in chickens. Surprisingly, although we identified orthologues of INK4b and ARF, chickens do not encode an equivalent of INK4a. Moreover, the reading frame for chicken ARF does not extend into exon 2, because splicing occurs in a different register to that used in mammals. The resultant 60-aa product nevertheless shares functional attributes with its mammalian counterparts. As well as indicating that the locus has been subject to dynamic evolutionary pressures, these unexpected findings suggest that in chickens, the tumor-suppressor functions of INK4a have been compensated for by other genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.