ArticleDevelopment (Cambridge, England)2003
Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila.
Article in Development (Cambridge, England), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Engrailed-1 in eccrine sweat gland development and regeneration: from evolutionary innovation to therapeutic perspectives.Frontiers in cell and developmental biology · 2026Review
- Homothorax controls a binary Rhodopsin switch in Drosophila ocelli.PLoS genetics · 2021Article
- Comparative transcriptome analyses of the Drosophila pupal eye.G3 (Bethesda, Md.) · 2021Article
- TALE factors use two distinct functional modes to control an essential zebrafish gene expression program.eLife · 2018Article
- Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins elbow and no ocelli.PLoS genetics · 2014Article
- Homothorax and Extradenticle alter the transcription factor network in Drosophila ommatidia at the dorsal rim of the retina.Development (Cambridge, England) · 2014Article
- Hox regulation of transcription: more complex(es).Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired.Developmental biology · 2012Article
- Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers.Developmental biology · 2012Article
- Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Genome-level identification of targets of Hox protein Ultrabithorax in Drosophila: novel mechanisms for target selection.Scientific reports · 2011Article
- Chromosomal binding sites of the homeotic cofactor Homothorax.Molecular genetics and genomics : MGG · 2008Article
- Compartmental modulation of abdominal Hox expression by engrailed and sloppy-paired patterns the fly ectoderm.Developmental biology · 2007Article
- Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon.Molecular and cellular biology · 2007Article
- Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries.Developmental biology · 2007Article
- The evolution of hexapod engrailed-family genes: evidence for conservation and concerted evolution.Proceedings. Biological sciences · 2006Article
- Drawing lines in the sand: even skipped et al. and parasegment boundaries.Developmental biology · 2004Article
- Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20.Mechanisms of developmentArticle
- Evolution of an insect-specific GROUCHO-interaction motif in the ENGRAILED selector protein.Evolution & developmentArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Engrailed is a key transcriptional regulator in the nervous system and in the maintenance of developmental boundaries in Drosophila, and its vertebrate homologs regulate brain and limb development. Here, we show that the functions of both of the Hox cofactors Extradenticle and Homothorax play essential roles in repression by Engrailed. Mutations that remove either of them abrogate the ability of Engrailed to repress its target genes in embryos, both cofactors interact directly with Engrailed, and both stimulate repression by Engrailed in cultured cells. We suggest a model in which Engrailed, Extradenticle and Homothorax function as a complex to repress Engrailed target genes. These studies expand the functional requirements for extradenticle and homothorax beyond the Hox proteins to a larger family of non-Hox homeodomain proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.