ArticleDevelopment (Cambridge, England)2003
Roles of myosin phosphatase during Drosophila development.
Article in Development (Cambridge, England), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Bridges under construction: the dynamics of ring canal expansion during Drosophila oogenesis.Developmental biology · 2026Review
- A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation.Disease models & mechanisms · 2026Article
- Ecdysone signaling-induced dumpless1 expression controls nurse cell dumping in Drosophila oogenesis.Nature communications · 2025Article
- [46,XY disorder of sex development caused byZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Article
- Mechanics of stabilized intercellular bridges.Biophysical journal · 2022Article
- Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction ineLife · 2021Article
- Cellular and Supracellular Planar Polarity: A Multiscale Cue to Elongate theFrontiers in cell and developmental biology · 2021Review
- TheMolecular biology of the cell · 2020Article
- Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.American journal of human genetics · 2020Article
- A biochemical network controlling basal myosin oscillation.Nature communications · 2018Article
- Review
- Actomyosin meshwork mechanosensing enables tissue shape to orient cell force.Nature communications · 2017Article
- Myosin phosphatase Fine-tunes Zebrafish Motoneuron Position during Axonogenesis.PLoS genetics · 2016Article
- Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis.The Journal of cell biology · 2014Article
- A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes.Nature cell biology · 2013Article
- Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.PloS one · 2013Article
- Protein phosphatase 1 β paralogs encode the zebrafish myosin phosphatase catalytic subunit.PloS one · 2013Article
- Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity.The Journal of cell biology · 2012Article
- Structure and functions of stable intercellular bridges formed by incomplete cytokinesis during development.Communicative & integrative biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Myosins are a superfamily of actin-dependent molecular motor proteins, among which the bipolar filament forming myosins II have been the most studied. The activity of smooth muscle/non-muscle myosin II is regulated by phosphorylation of the regulatory light chains, that in turn is modulated by the antagonistic activity of myosin light chain kinase and myosin light chain phosphatase. The phosphatase activity is mainly regulated through phosphorylation of its myosin binding subunit MYPT. To identify the function of these phosphorylation events, we have molecularly characterized the Drosophila homologue of MYPT, and analyzed its mutant phenotypes. We find that Drosophila MYPT is required for cell sheet movement during dorsal closure, morphogenesis of the eye, and ring canal growth during oogenesis. Our results indicate that the regulation of the phosphorylation of myosin regulatory light chains, or dynamic activation and inactivation of myosin II, is essential for its various functions during many developmental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.