ArticleJournal of virology2003
Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
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- Correlation between congenital heart disease complicated with pulmonary artery hypertension and circulating endothelial cells as well as endothelin-1.International journal of clinical and experimental pathology · 2015Article
- Differential lymphocyte and antibody responses in deer mice infected with Sin Nombre hantavirus or Andes hantavirus.Journal of virology · 2014Article
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- An ITAM in a nonenveloped virus regulates activation of NF-κB, induction of beta interferon, and viral spread.Journal of virology · 2014Article
- Hantavirus GnT elements mediate TRAF3 binding and inhibit RIG-I/TBK1-directed beta interferon transcription by blocking IRF3 phosphorylation.Journal of virology · 2014Article
- The fundamental role of endothelial cells in hantavirus pathogenesis.Frontiers in microbiology · 2014Article
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- Kinetics of immune responses in deer mice experimentally infected with Sin Nombre virus.Journal of virology · 2012Article
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- Hantavirus regulation of type I interferon responses.Advances in virology · 2012Article
- Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir.Antiviral chemistry & chemotherapy · 2011Article
- The C-terminal 42 residues of the Tula virus Gn protein regulate interferon induction.Journal of virology · 2011Article
- Characterization of two substrains of Puumala virus that show phenotypes that are different from each other and from the original strain.Journal of virology · 2011Article
- Recent advances in hantavirus molecular biology and disease.Advances in applied microbiology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Hantaviruses infect human endothelial and immune cells, causing two human diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). We have identified key signaling elements termed immunoreceptor tyrosine-based activation motifs (ITAMs) within the G1 cytoplasmic tail of all HPS-causing hantaviruses. ITAMs direct receptor signaling within immune and endothelial cells and the presence of ITAMs in all HPS-causing hantaviruses provides a means for altering normal cellular responses which maintain vascular integrity. The NY-1 G1 ITAM was shown to coprecipitate a complex of phosphoproteins from cells, and the G1 ITAM is a substrate for the Src family kinase Fyn. The hantavirus ITAM coprecipitated Lyn, Syk, and ZAP-70 kinases from T or B cells, while mutagenesis of the ITAM abolished these interactions. In addition, G1 ITAM tyrosines directed intracellular interactions with Syk by mammalian two-hybrid analysis. These findings demonstrate that G1 ITAMs bind key cellular kinases that regulate immune and endothelial cell functions. There is currently no means for establishing the role of the G1 ITAM in hantavirus pathogenesis. However, the conservation of G1 ITAMs in all HPS-causing hantaviruses and the role of these signaling elements in immune and endothelial cells suggest that functional G1 ITAMs are likely to dysregulate normal immune and endothelial cell responses and contribute to hantavirus pathogenesis.
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