ArticleJournal of virology2003
Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Article
- Respiratory Epithelial Cells Respond toViruses · 2020Article
- Review
- Preventing Mortality in COVID-19 Patients: Which Cytokine to Target in a Raging Storm?Frontiers in cell and developmental biology · 2020Article
- Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice.Antiviral research · 2016Article
- Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection.Antiviral research · 2015Article
- Article
- Article
- Lactobacillus priming of the respiratory tract: Heterologous immunity and protection against lethal pneumovirus infection.Antiviral research · 2013Article
- Innate and adaptive immune response to pneumonia virus of mice in a resistant and a susceptible mouse strain.Viruses · 2013Article
- Review
- IL-21 promotes the pathologic immune response to pneumovirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Depletion of alveolar macrophages prolongs survival in response to acute pneumovirus infection.Virology · 2012Article
- Inflammatory responses to respiratory syncytial virus (RSV) infection and the development of immunomodulatory pharmacotherapeutics.Current medicinal chemistry · 2012Review
- Lactobacillus-mediated priming of the respiratory mucosa protects against lethal pneumovirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Inflammatory responses to acute pneumovirus infection in neonatal mice.Virology journal · 2010Article
- MicroRNome analysis unravels the molecular basis of SARS infection in bronchoalveolar stem cells.PloS one · 2009Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
We report here the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. Mice infected with pneumonia virus of mice, a natural mouse pathogen that replicates the signs and symptoms of severe infection with respiratory syncytial virus (RSV), responded to the antiviral agent ribavirin when it was administered in the setting of endogenous (gene deletion) or exogenous (antibody-mediated) blockade of the MIP-1alpha proinflammatory signaling cascade. Although neither treatment is effective alone, together they offer a dramatic reduction in symptoms and pathology, the most impressive of which is a significant reduction in morbidity and mortality. The findings presented are consistent with the notion of unique and independent contributions of virus replication and ongoing inflammation to the pathogenesis of severe respiratory virus infection, and they provide the impetus for the study of this treatment regimen in RSV-infected humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.