ArticleInternational immunology2003
Prolonged presence of effector-memory CD8 T cells in the central nervous system after dengue virus encephalitis.
Article in International immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Brain-infiltrating CD8 T cells retain functional activity to protect against acute Zika virus infection.Scientific reports · 2026Article
- Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson's Disease.International journal of molecular sciences · 2024Review
- Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy.Nature communications · 2021Article
- Neuroinflammation During RNA Viral Infections.Annual review of immunology · 2019Review
- Inflammation, Infectious Triggers, and Parkinson's Disease.Frontiers in neurology · 2019Review
- Tissue-resident memory T cells.Immunity · 2014Review
- The role of innate and adaptive immunity in Parkinson's disease.Journal of Parkinson's disease · 2013Review
- CD8+ T cells primed in the periphery provide time-bound immune-surveillance to the central nervous system.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection.BMC immunology · 2011Article
- DNA vaccines against dengue virus type 2 based on truncate envelope protein or its domain III.PloS one · 2011Article
- Diversity in T cell memory: an embarrassment of riches.Immunity · 2009Review
- Antigen display, T-cell activation, and immune evasion during acute and chronic ehrlichiosis.Infection and immunity · 2009Article
- Migration, maintenance and recall of memory T cells in peripheral tissues.Nature reviews. Immunology · 2009Review
- IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection.Journal of neuroimmunology · 2009Article
- Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification.Virology journal · 2007Article
- Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Latent infection with herpes simplex virus is associated with ongoing CD8+ T-cell stimulation by parenchymal cells within sensory ganglia.Journal of virology · 2005Article
- Virus-specific and bystander CD8 T cells recruited during virus-induced encephalomyelitis.Journal of virology · 2005Article
- Increased epitope-specific CD8+ T cells prevent murine coronavirus spread to the spinal cord and subsequent demyelination.Journal of virology · 2005Article
- T-cells in human encephalitis.Neuromolecular medicine · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dengue virus infection in the central nervous system (CNS) of immunized mice results in a strong influx of CD8 T cells into the brain. Whereas the kinetics of the splenic antiviral response are conventional, i.e. expansion followed by a rapid drop in the frequency of specific CD8 T cells, dengue virus-specific CD8 T cells are retained in the CNS at a high frequency. These CD8 T cells display a partially activated phenotype (CD69(high), Ly-6A/E(high), CD62L(low)), characteristic for effector-memory T cells. CD43 expression, visualized by staining with the 1B11 mAb, decreased in time, suggesting that these persisting CD8 T cells differentiated into memory cells. These data add to the growing evidence implicating the CNS as a non-lymphoid tissue capable of supporting prolonged T cell survival/maintenance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.