ArticleJournal of muscle research and cell motility2002
Partial fast-to-slow conversion of regenerating rat fast-twitch muscle by chronic low-frequency stimulation.
Article in Journal of muscle research and cell motility, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
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- Frequency-dependent effects of superimposed NMES on spinal excitability in upper and lower limb muscles.Heliyon · 2024Article
- Improving reaching with functional electrical stimulation by incorporating stiffness modulation.Journal of neural engineering · 2021Article
- Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery.Frontiers in physiology · 2018Article
- Comparison of morphological changes of muscle fibers in response to dynamic electrical muscle contraction and dynamic hydraulic stimulation in a rat hindlimb disuse model.Physiological research · 2017Article
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- Myosin Heavy Chain Expression Can Vary over the Length of Jaw and Leg Muscles.Cells, tissues, organs · 2016Article
- Intrinsic transient tracheal occlusion training and myogenic remodeling of rodent parasternal intercostal fibers.Journal of rehabilitation research and development · 2014Article
- Developing laryngeal muscle of Xenopus laevis as a model system: androgen-driven myogenesis controls fiber type transformation.Developmental neurobiology · 2012Article
- Effect of satellite cell ablation on low-frequency-stimulated fast-to-slow fibre-type transitions in rat skeletal muscle.The Journal of physiology · 2006Article
- "Fast" and "slow" muscle fibres in hindlimb muscles of adult rats regenerate from intrinsically different satellite cells.The Journal of physiology · 2005Article
- NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Changes in contractile activation characteristics of rat fast and slow skeletal muscle fibres during regeneration.The Journal of physiology · 2004Article
- Impact of electrical stimulation on three-dimensional myoblast cultures - a real-time RT-PCR study.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic low-frequency stimulation (CLFS) of rat fast-twitch muscles induces sequential transitions in myosin heavy chain (MHC) expression from MHCIIb --> MHCIId/x --> MHCIIa. However, the 'final' step of the fast-to-slow transition, i.e., the upregulation of MHCI, has been observed only after extremely long stimulation periods. Assuming that fibre degeneration/regeneration might be involved in the upregulation of slow myosin, we investigated the effects of CLFS on extensor digitorum longus (EDL) muscles regenerating after bupivacaine-induced fibre necrosis. Normal, non-regenerating muscles responded to both 30- and 60-day CLFS with fast MHC isoform transitions (MHCIIb --> MHCIId --> MHCIIa) and only slight increases in MHCI. CLFS of regenerating EDL muscles caused similar transitions among the fast isoforms but, in addition, caused significant increases in MHCI (to approximately 30% relative concentration). Stimulation periods of 30 and 60 days induced similar changes in the regenerating bupivacaine-treated muscles, indicating that the upregulation of slow myosin was restricted to regenerating fibres, but only during an early stage of regeneration. These results suggest that satellite cells and/or regenerating fast rat muscle fibres are capable of switching directly to a slow program under the influence of CLFS and, therefore, appear to be more malleable than adult fibres.
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