ArticleDigestive diseases and sciences2002
Radiation-induced crypt intestinal epithelial cell apoptosis in vivo involves both caspase-3-dependent and -independent pathways.
Article in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery.Antioxidants (Basel, Switzerland) · 2019Article
- Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Long-term melatonin administration attenuates low-LET gamma-radiation-induced lymphatic tissue injury during the reproductively active and inactive phases of Indian palm squirrels (Funambulus pennanti).The British journal of radiology · 2010Article
- Role of bone marrow-derived monocytes/macrophages in the repair of mucosal damage caused by irradiation and/or anticancer drugs in colitis model.Mediators of inflammation · 2010Article
- Intestinal redox status of major intracellular thiols in a rat model of chronic alcohol consumption.JPEN. Journal of parenteral and enteral nutritionArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Caspases play a major role in virtually all forms of apoptosis. Radiation is well known to induce apoptosis of crypt intestinal epithelial cells (IEC). Here, we examined the role of caspase-3 in radiation-induced IEC apoptosis. We demonstrate that while caspase-3 is present in IEC and activated upon irradiation, IEC in caspase-3-deficient mice partially underwent radiation-induced apoptosis. Typical morphological changes of IEC undergoing radiation-induced apoptosis (ie, blebbing, shrinkage, and nuclear condensation) can occur independently of caspase-3; however DNA fragmentation, as analyzed by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining, is mostly, but not entirely, caspase-3-dependent. Overall, these results demonstrate that radiation-induced crypt IEC apoptosis has both caspase-3-independent and -dependent components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.