SynthesisPostgraduate medical journal2002
Magnesium in stroke treatment.
Synthesis in Postgraduate medical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06956521 (Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy in Acute Ischemic Stroke), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy in Acute Ischemic Stroke
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Excitatory amino acid antagonists for acute stroke.The Cochrane database of systematic reviews · 2003Pooled it
- Protective Effects of Intravenous Magnesium Sulfate in Stroke Patients Receiving Amiodarone: A Randomized Controlled Trial.Advances in experimental medicine and biology · 2021Trial
- Trial
- Trial
- High dose magnesium infusions are not associated with increased pressor requirements after carotid endarterectomy.Neurosurgery · 2006Trial
- Article
- Advances in the Treatment of Autism Spectrum Disorder: Current and Promising Strategies.Current medicinal chemistry · 2024Review
- The Development of Novel Drug Treatments for Stroke Patients: A Review.International journal of molecular sciences · 2022Review
- Rapid Treatment with Intramuscular Magnesium Sulfate During Cardiopulmonary Resuscitation Does Not Provide Neuroprotection Following Cardiac Arrest.Molecular neurobiology · 2022Article
- Intraoperative continuous cerebral microcirculation measurement in patients with aneurysmal subarachnoid hemorrhage: preliminary data on the early administration of magnesium sulfate.BMC anesthesiology · 2017Article
- Magnesium in obstetric anesthesia and intensive care.Journal of anesthesia · 2017Review
- Acute decrease in serum magnesium level after ischemic stroke may not predict decrease in neurologic function.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2013Article
- The science of cerebral ischemia and the quest for neuroprotection: navigating past failure to future success.Journal of neurosurgery · 2013Review
- Article
- Neuroprotection in cerebral ischemia: emphasis on the SAINT trial.Current cardiology reports · 2008Review
- Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion.The Journal of membrane biology · 2007Review
- Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage.Critical care (London, England) · 2007Review
- The search for neuroprotective strategies in stroke.AJNR. American journal of neuroradiology · 2004Review
- Clinical trials for cytoprotection in stroke.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium is involved in multiple physiological processes that may be relevant to cerebral ischaemia, including antagonism of glutamate release, NMDA receptor blockade, calcium channel antagonism, and maintenance of cerebral blood flow. Systemically administered magnesium at doses that double physiological serum concentration significantly reduces infarct volume in animal models of stroke, with a window of up to six hours after onset and favourable dose-response characteristics when compared with previously tested neuroprotective agents. Small clinical trials have reported benefit, but results are not statistically significant in systematic review. A large ongoing trial (IMAGES) will report in 2003-4 and further trials are planned.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.