ArticleInfection and immunity2003
Association of Helicobacter pylori antioxidant activities with host colonization proficiency.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 78 citations in OpenAlex.
- Linoleic Hydroperoxides Are Potent Hyperoxidative Agents of Sensitive and Robust Typical 2-Cys Peroxiredoxins.Antioxidants (Basel, Switzerland) · 2025Article
- Cold-adapted characteristics and gene knockout of alkyl hydroperoxide reductase subunit C in Antarctic Psychrobacter sp. ANT206.World journal of microbiology & biotechnology · 2024Article
- Article
- Positive Selection of Mutations in the Helicobacter pyloriInfection and immunity · 2022Article
- Relevance of peroxiredoxins in pathogenic microorganisms.Applied microbiology and biotechnology · 2021Review
- Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise.Free radical biology & medicine · 2017Review
- Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity.FEMS microbiology reviews · 2016Article
- Genetic Diversity as Consequence of a Microaerobic and Neutrophilic Lifestyle.PLoS pathogens · 2016Article
- Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses.Cancer research · 2016Article
- Kinetic characterization of a novel acid ectophosphatase from Enterobacter asburiae.Journal of microbiology (Seoul, Korea) · 2016Article
- Tuning of peroxiredoxin catalysis for various physiological roles.Biochemistry · 2014Review
- Clinical proteomics identifies potential biomarkers in Helicobacter pylori for gastrointestinal diseases.World journal of gastroenterology · 2014Review
- Alkyl hydroperoxide reductase repair by Helicobacter pylori methionine sulfoxide reductase.Journal of bacteriology · 2013Article
- Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice.Gastroenterology · 2013Article
- Plasmid diversity in arctic strains of Psychrobacter spp.Extremophiles : life under extreme conditions · 2013Article
- Construction and use of a prokaryotic expression system for Helicobacter pylori AhpC.BMC research notes · 2012Article
- Comparative study of the roles of AhpC and KatE as respiratory antioxidants in Brucella abortus 2308.Journal of bacteriology · 2010Article
- Surreptitious manipulation of the human host by Helicobacter pylori.Gut microbes · 2010Article
- Structural changes common to catalysis in the Tpx peroxiredoxin subfamily.Journal of molecular biology · 2009Article
- Mutation of cytotoxin-associated gene A affects expressions of antioxidant proteins of Helicobacter pylori.World journal of gastroenterology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To assess the importance of two separate antioxidant activities in Helicobacter pylori, we tested the abilities of strains with mutations in either tpx (encoding thiolperoxidase) or ahpC (encoding alkyl hydroperoxide reductase [AhpC]) to colonize the stomachs of mice. The tpx strain was clearly more sensitive than the parent strain to both oxygen and cumene hydroperoxide. The strain colonized only 5% of the inoculated mice. Two different classes of oxygen-sensitive ahpC mutants in the type strain (ATCC 43504) were recently described (A. A. Olczak, J. W. Olson, and R. J. Maier, J. Bacteriol. 184:3186-3193, 2002). The same two classes of mutants were recovered upon ahpC mutagenesis of the mouse-adapted strain, SS1. Neither of these mutants was able to colonize mouse stomachs, whereas 78% of the mice inoculated with the parent strain became H. pylori positive.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.