ArticleInfection and immunity2003
Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- The role of type IV pilus in the interaction ofInfection and immunity · 2026Article
- IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube.Nature communications · 2024Article
- Mechanisms of host manipulation byFrontiers in microbiology · 2023Review
- BothPathogens (Basel, Switzerland) · 2022Article
- Tissue Models forFrontiers in cellular and infection microbiology · 2022Review
- The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility.International journal of molecular sciences · 2021Review
- Potential of Mesenchymal Stem Cell-Derived Exosomes as a Novel Treatment for Female Infertility Caused by Bacterial Infections.Frontiers in microbiology · 2021Review
- Antibiotic Targets in Gonococcal Cell Wall Metabolism.Antibiotics (Basel, Switzerland) · 2018Review
- Pathogenesis ofFrontiers in immunology · 2018Review
- Modified Profile of Matrix Metalloproteinase 2 and 9 Production by Human Fallopian Tube Epithelial Cells After Infection In Vitro With Neisseria gonorrhoeae.The Journal of infectious diseases · 2017Article
- Article
- Neisseria gonorrhoeae survives within and modulates apoptosis and inflammatory cytokine production of human macrophages.Cellular microbiology · 2016Article
- Estrogen Receptor Alpha (ESR1)-Dependent Regulation of the Mouse Oviductal Transcriptome.PloS one · 2016Article
- Talking about links between sexually transmitted infections and infertility with college and university students from SE England, UK: a qualitative study.Reproductive health · 2013Article
- Peptidoglycan fragment release from Neisseria meningitidis.Infection and immunity · 2013Article
- The lytic transglycosylases of Neisseria gonorrhoeae.Microbial drug resistance (Larchmont, N.Y.) · 2012Review
- Neisseria gonorrhoeae pilus attenuates cytokine response of human fallopian tube explants.Journal of biomedicine & biotechnology · 2012Article
- Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses.Infection and immunity · 2010Article
- Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins.Infection and immunity · 2009Article
- Differential modulation of TNF-alpha-induced apoptosis by Neisseria meningitidis.PLoS pathogens · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection of the Fallopian tubes (FT) by Neisseria gonorrhoeae can lead to acute salpingitis, an inflammatory condition, which is a major cause of infertility. Challenge of explants of human FT with gonococci induced mRNA expression and protein secretion for the proinflammatory cytokines interleukin (IL)-1alpha, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) but not for granulocyte-macrophage colony-stimulating factor. In contrast, FT expression of IL-6 and of the cytokine receptors IL-6R, TNF receptor I (TNF-RI), and TNF-RII was constitutive and was not increased by gonococcal challenge. These studies suggest that several proinflammatory cytokines are likely to contribute to the cell and tissue damage observed in gonococcal salpingitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.