ArticleInfection and immunity2003
Roles of the Maltese cross form in the development of parasitemia and protection against Babesia microti infection in mice.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Cross-species therapeutics in Plasmodium and Babesia: erythrocyte invasion and conserved drug targets.Tropical animal health and production · 2026Review
- A Highly Sensitive Multiplex Antibody Assay Reduces Window Period for Detection ofOpen forum infectious diseases · 2025Article
- Protective efficacy and correlates of immunity of immunodominant recombinantInfection and immunity · 2023Article
- Article
- A Novel Thioredoxin-Like Protein ofFrontiers in cellular and infection microbiology · 2022Article
- A library of recombinant Babesia microti cell surface and secreted proteins for diagnostics discovery and reverse vaccinology.International journal for parasitology · 2019Article
- Performance and consistency of a fluorescence-based high-throughput screening assay for use in Babesia drug screening in mice.Scientific reports · 2017Article
- Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions.Scientific reports · 2016Article
- Inclusion bodies in tick-borne diseases diagnosed in patients from northern Wisconsin.Clinical medicine & research · 2009Article
- Roles of the Maltese cross form of Babesia microti in the development of parasitemia in B. microti infection.Infection and immunity · 2004Article
- Growth-inhibitory effect of heparin on Babesia parasites.Antimicrobial agents and chemotherapy · 2004Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Babesia microti, a hemoprotozoan parasite of rodents, is also important as a zoonotic agent of human babesiosis. The Maltese cross form, which consists of four masses in an erythrocyte, is characteristic of the developmental stage of B. microti. Monoclonal antibody (MAb) 2-1E, which specifically recognizes the Maltese cross form of B. microti, has been described previously. In the present study, we examined the roles of the Maltese cross form during the infectious course of B. microti in mice. The number of the Maltese cross form increased in the peripheral blood of infected mice prior to the peak of parasitemia. With confocal laser scanning microscopy, MAb 2-1E was found to be reactive with the ring form, with the parasites undergoing transformation to the Maltese cross form and subsequent division, and also with extracellular merozoites. Furthermore, the Maltese cross form-related antigen (MRA) gene was isolated from a B. microti cDNA library by immunoscreening with MAb 2-1E, and the nucleotide sequence was determined. Genomic analyses indicated that the MRA gene exists as a single-copy gene in B. microti. Immunization of mice with recombinant MRA induced significant protective immunity against B. microti infection. These findings indicate that the Maltese cross form plays important roles in both the development of parasitemia and the protective response against the infection.
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