ArticleInfection and immunity2003
Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar typhimurium.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Advances in the development of Salmonella-based vaccine strategies for protection against Salmonellosis in humans.Journal of applied microbiology · 2021Review
- Immunogenicity and Efficacy of Live-AttenuatedInfection and immunity · 2021Article
- Asymmetric division yields progeny cells with distinct modes of regulating cell cycle-dependent chromosome methylation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Bacterial proteases, untapped antimicrobial drug targets.The Journal of antibiotics · 2017Review
- Utilization of Mechanistic Enzymology to Evaluate the Significance of ADP Binding to Human Lon Protease.Frontiers in molecular biosciences · 2017Article
- Salmonella enterica serovar Typhimurium utilizes the ClpPX and Lon proteases for optimal fitness in the ceca of chickens.Poultry science · 2016Article
- Virulence Associated Genes-DeletedFrontiers in microbiology · 2016Article
- Evaluation of the live vaccine efficacy of virulence plasmid-cured, and phoP- or aroA-deficient Salmonella enterica serovar Typhimurium in mice.The Journal of veterinary medical science · 2015Article
- Salmonella Typhimurium TTSS-2 deficient mig-14 mutant shows attenuation in immunocompromised mice and offers protection against wild-type Salmonella Typhimurium infection.BMC microbiology · 2013Article
- Enterobacterial common antigen mutants of Salmonella enterica serovar Typhimurium establish a persistent infection and provide protection against subsequent lethal challenge.Infection and immunity · 2012Article
- Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strains.Infection and immunity · 2011Article
- Review
- Salmonella enterica serovar Typhimurium lacking hfq gene confers protective immunity against murine typhoid.PloS one · 2011Article
- Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates.Biochimica et biophysica acta · 2008Review
- Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC infectious diseases · 2008Article
- Flagella facilitate escape of Salmonella from oncotic macrophages.Journal of bacteriology · 2007Article
- Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.Biochemistry · 2006Article
- Azithromycin inhibits the formation of flagellar filaments without suppressing flagellin synthesis in Salmonella enterica serovar typhimurium.Antimicrobial agents and chemotherapy · 2005Article
- Salmonella flagellin is not a dominant protective antigen in oral immunization with attenuated live vaccine strains.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the efficacy of mutants with a deletion of the stress response protease gene as candidates for live oral vaccine strains against Salmonella infection through infection studies with mice by using a Salmonella enterica serovar Typhimurium mutant with a disruption of the ClpXP or Lon protease. In vitro, the ClpXP protease regulates flagellum synthesis and the ClpXP-deficient mutant strain exhibits hyperflagellated bacterial cells (T. Tomoyasu et al., J. Bacteriol. 184:645-653, 2002). On the other hand, the Lon protease negatively regulates the efficacy of invading epithelial cells and the expression of invasion genes (A. Takaya et al., J. Bacteriol. 184:224-232, 2002). When 5-week-old BALB/c mice were orally administered 5 x 10(8) CFU of the ClpXP- or Lon-deficient strain, bacteria were detected with 10(3) to 10(4) CFU in the spleen, mesenteric lymph nodes, Peyer's patches, and cecum 1 week after inoculation and the bacteria then decreased gradually in each tissue. Significant increases of lipopolysaccharide-specific immunoglobulin G (IgG) and secretory IgA were detected at week 4 and maintained until at least week 12 after inoculation in serum and bile, respectively. Immunization with the ClpXP- or Lon-deficient strain protected mice against oral challenge with the serovar Typhimurium virulent strain. Both the challenged virulent and immunized avirulent salmonellae were completely cleared from the spleen, mesenteric lymph nodes, Peyer's patches, and even cecum 5 days after the challenge. These data indicate that Salmonella with a disruption of the ATP-dependent protease ClpXP or Lon can be useful in developing a live vaccine strain.
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