ArticleInfection and immunity2003
Resistance of macrophages to Mycobacterium avium is induced by alpha2-adrenergic stimulation.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- Effects of serum from breast cancer surgery patients receiving perioperative dexmedetomidine on breast cancer cell malignancy: A prospective randomized controlled trial.Cancer medicine · 2019Trial
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- Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial.Critical care (London, England) · 2010Trial
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- Adrenergic orchestration of immune cell dynamics in response to cardiac stress.Journal of molecular and cellular cardiology · 2024Review
- Role of dexmedetomidine in modifying immune paralysis in patients with septic shock: randomized controlled trial.Intensive care medicine experimental · 2023Article
- Dexmedetomidine improves the outcomes for pediatric severe sepsis with mechanical ventilation.BMC pediatrics · 2023Article
- Adrenergic signaling regulation of macrophage function: do we understand it yet?Immunotherapy advances · 2022Review
- Autonomic nervous system and inflammation interaction in endometriosis-associated pain.Journal of neuroinflammation · 2020Review
- Intra-Species and Inter-Kingdom Signaling ofFrontiers in microbiology · 2017Review
- The evolving approach to sedation in ventilated patients: a real world perspective.Annals of translational medicine · 2016Article
- Activation of α2 adrenoceptor attenuates lipopolysaccharide-induced hepatic injury.International journal of clinical and experimental pathology · 2015Article
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- Stressor-induced increase in microbicidal activity of splenic macrophages is dependent upon peroxynitrite production.Infection and immunity · 2012Article
- The intestinal microbiota are necessary for stressor-induced enhancement of splenic macrophage microbicidal activity.Brain, behavior, and immunity · 2012Article
- Social stress enhances IL-1beta and TNF-alpha production by Porphyromonas gingivalis lipopolysaccharide-stimulated CD11b+ cells.Physiology & behavior · 2009Article
- Sedation improves early outcome in severely septic Sprague Dawley rats.Critical care (London, England) · 2009Article
- Review
- Mycobacterium avium-intracellulare contamination of mammalian cell cultures.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The ability of macrophages to control the growth of microorganisms is increased by macrophage activation. Previously, it was shown that epinephrine activated mouse macrophages to resist the growth of Mycobacterium avium via alpha(2)-adrenergic stimulation. In the present study, we show that the alpha(2)-adrenergic agonist (alpha(2)-agonist) clonidine induced resistance to M. avium growth in the RAW264.7 mouse macrophage cell line. The ability of catecholamines to induce resistance to mycobacteria was specific to alpha(2)-adrenergic stimulation, as alpha(1)-, beta(1)-, and beta(2)-agonists had no effect. Receptor signaling through Gi proteins was required. A G-protein antagonist specific for the alpha subunits of the Go/Gi family blocked the increased resistance induced by clonidine, while a Gs-protein antagonist was without effect. Both nitric oxide (NO) production and superoxide (O(2)(-)) production were required for the increased resistance to M. avium growth induced by clonidine. Although NO production was required, clonidine did not increase the level of NO in M. avium-infected cells. Since NO and O(2)(-) interact to produce peroxynitrite (ONOO(-)), we examined whether ONOO(-) mediates the increased resistance to M. avium induced by clonidine. 5,10,15,20-Tetrakis(4-sulfonatophenyl)prophyrinato iron (III) chloride (FeTPPS), a specific scavenger of ONOO(-), inhibited the effect of clonidine on M. avium growth. Clonidine also increased the production of ONOO(-) in M. avium-infected RAW264.7 cells, as measured by the oxidation of 123-dihydrorhodamine and the production of nitrated tyrosine residues. We therefore conclude that alpha(2)-adrenergic stimulation activates macrophages to resist the growth of M. avium by enhancing the production of ONOO(-).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.