ArticleBiophysical journal2002
Staggering of subunits in NMDAR channels.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Correlated conformational dynamics of the human GluN1-GluN2A type N-methyl-D-aspartate (NMDA) receptor.Journal of molecular modeling · 2021Article
- Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing.The Journal of general physiology · 2019Article
- Structure, function, and allosteric modulation of NMDA receptors.The Journal of general physiology · 2018Review
- Properties of TriheteromericMolecular pharmacology · 2018Article
- Structural modeling for the open state of an NMDA receptor.Journal of structural biology · 2017Article
- Gating Motions and Stationary Gating Properties of Ionotropic Glutamate Receptors: Computation Meets Electrophysiology.Accounts of chemical research · 2017Review
- NMDA Receptors in the Central Nervous System.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Binding of ArgTX-636 in the NMDA receptor ion channel.Journal of molecular biology · 2015Article
- Glutamate receptor pores.The Journal of physiology · 2015Review
- Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy.Nature communications · 2014Article
- Radial symmetry in a chimeric glutamate receptor pore.Nature communications · 2014Article
- A novel alcohol-sensitive position in the N-methyl-D-aspartate receptor GluN2A subunit M3 domain regulates agonist affinity and ion channel gating.Molecular pharmacology · 2013Article
- An NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.Biophysical journal · 2013Article
- Key binding interactions for memantine in the NMDA receptor.ACS chemical neuroscience · 2013Article
- GluN3A: an NMDA receptor subunit with exquisite properties and functions.Neural plasticity · 2013Review
- Probing the activation sequence of NMDA receptors with lurcher mutations.The Journal of general physiology · 2012Article
- Glutamate neurocircuitry: theoretical underpinnings in schizophrenia.Frontiers in pharmacology · 2012Article
- Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesis.The Journal of general physiology · 2010Article
- Glutamate receptor ion channels: structure, regulation, and function.Pharmacological reviews · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Functional N-methyl-D-aspartate receptors (NMDARs) are heteromultimers formed by NR1 and NR2 subunits. The M3 segment, as contributed by NR1, forms the core of the extracellular vestibule, including binding sites for channel blockers, and represents a critical molecular link between ligand binding and channel opening. Taking advantage of the substituted cysteine accessibility method along with channel block and multivalent coordination, we studied the contribution of the M3 segment in NR2C to the extracellular vestibule. We find that the M3 segment in NR2C, like that in NR1, contributes to the core of the extracellular vestibule. However, the M3 segments from the two subunits are staggered relative to each other in the vertical axis of the channel. Compared to NR1, homologous positions in NR2C, including those in the highly conserved SYTANLAAF motif, are located about four amino acids more externally. The staggering of subunits may represent a key structural feature underlying the distinct functional properties of NMDARs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.