ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2002
No accident: genetic codes freeze in error-correcting patterns of the standard genetic code.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Ordering events in a developing genetic code.RNA biology · 2024Article
- A crescendo of competent coding (c3) contains the Standard Genetic Code.RNA (New York, N.Y.) · 2022Article
- The influence of different types of translational inaccuracies on the genetic code structure.BMC bioinformatics · 2019Article
- An alternative look at code evolution: using non-canonical codes to evaluate adaptive and historic models for the origin of the genetic code.Journal of molecular evolution · 2013Article
- CMCpy: Genetic Code-Message Coevolution Models in Python.Evolutionary bioinformatics online · 2013Article
- Simulated evolution applied to study the genetic code optimality using a model of codon reassignments.BMC bioinformatics · 2011Article
- Optimization models and the structure of the genetic code.Journal of molecular evolution · 2009Review
- A four-column theory for the origin of the genetic code: tracing the evolutionary pathways that gave rise to an optimized code.Biology direct · 2009Article
- Origin and evolution of the genetic code: the universal enigma.IUBMB life · 2009Review
- Article
- Evolution of the genetic code: partial optimization of a random code for robustness to translation error in a rugged fitness landscape.Biology direct · 2007Article
- The mechanisms of codon reassignments in mitochondrial genetic codes.Journal of molecular evolution · 2007Article
- The coevolution of genes and genetic codes: Crick's frozen accident revisited.Journal of molecular evolution · 2006Review
- Collective evolution and the genetic code.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Evolution of the genetic triplet code via two types of doublet codons.Journal of molecular evolution · 2005Article
- Do universal codon-usage patterns minimize the effects of mutation and translation error?Genome biology · 2005Article
- A new classification scheme of the genetic code.Journal of molecular evolution · 2004Article
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2 authors.
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Abstract
The standard genetic code poses a challenge in understanding the evolution of information processing at a fundamental level of biological organization. Genetic codes are generally coadapted with, or 'frozen' by, the protein-coding genes that they translate, and so cannot easily change by natural selection. Yet the standard code has a significantly non-random pattern that corrects common errors in the transmission of information in protein-coding genes. Because of the freezing effect and for other reasons, this pattern has been proposed not to be due to selection but rather to be incidental to other evolutionary forces or even entirely accidental. We present results from a deterministic population genetic model of code-message coevolution. We explicitly represent the freezing effect of genes on genetic codes and the perturbative effect of changes in genetic codes on genes. We incorporate characteristic patterns of mutation and translational error, namely, transition bias and positional asymmetry, respectively. Repeated selection over small successive changes produces genetic codes that are substantially, but not optimally, error correcting. In particular, our model reproduces the error-correcting patterns of the standard genetic code. Aspects of our model and results may be applicable to the general problem of adaptation to error in other natural information-processing systems.
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