ArticleEuropean journal of clinical nutrition2002
Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas.
Article in European journal of clinical nutrition, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.
- Human Milk Lipid Profiles around the World: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial.Nutrition journal · 2007Trial
- Integrated Protein-Lipid Digestion Profiles of Human Milk, Infant Formulas, and Dairy Ingredients Under Infant In Vitro Digestion.Foods (Basel, Switzerland) · 2026Article
- Bioengineered algal lipids enriched in structured medium- and long-chain triacylglycerols, linoleate, andbioRxiv : the preprint server for biology · 2026Article
- The Role of Food Structure on Fatty Acid Bioaccessibility: A Decade of TIM-1 Simulated Digestion Studies in Review.Molecular nutrition & food research · 2026Review
- Observational
- Structured Lipids Engineering for Health: Novel Formulations Enriched inMetabolites · 2023Review
- The Impact of Linoleic Acid on Infant Health in the Absence or Presence of DHA in Infant Formulas.Nutrients · 2023Review
- Association between Adherence to the Healthy Food Pyramid and Breast Milk Fatty Acids in the First Month of Lactation.Nutrients · 2022Article
- Fatty Acid Composition of Milk from Mothers with Normal Weight, Obesity, or Gestational Diabetes.Life (Basel, Switzerland) · 2022Article
- Production of human milk fat substitute by engineered strains ofMetabolic engineering communications · 2022Article
- Impact of pasteurization on the self-assembly of human milk lipids during digestion.Journal of lipid research · 2022Article
- Effect of Crushing Peanuts on Fatty Acid and Phenolic Bioaccessibility: A Long-Term Study.Antioxidants (Basel, Switzerland) · 2022Article
- Preparation of Human Milk Fat Substitutes: A Review.Life (Basel, Switzerland) · 2022Review
- Profiles of total and sn-2 fatty acid of human mature milk and their correlated factors: A cross-sectional study in China.Frontiers in nutrition · 2022Article
- Effects of Proteins and Mineral Ions on the Physicochemical Properties of 1,3-Dioleoyl-2-Palmitoylglycerol Emulsion to Mimic a Liquid Infant Formula.Frontiers in nutrition · 2022Article
- Improvements in extraction yield by solid phase lipid extraction from liquid infant formula and human milk, and the fatty acid distribution in milk TAG analyzed by joint JOCS/AOCS official method Ch 3a-19.Frontiers in nutrition · 2022Article
- The Role of Dietary Fats in the Development and Prevention of Necrotizing Enterocolitis.Nutrients · 2021Review
- Macronutrient content and fatty acid composition and their positional distribution in human breast milk from Zhejiang Province, China in different lactation periods.Food science & nutrition · 2021Article
- A Scoping Review of Clinical Studies in Infants Fed Formulas Containing Palm Oil or Palm Olein and Sn-2 Palmitate.The Journal of nutrition · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate differences in fatty acid and sn-2 fatty acid composition in colostrum, transitional and mature human milk, and in term infant formulas.
settingDepartament de Nutrició i Bromatologia, University of Barcelona, Spain and University Hospital of Granada, Spain. SUBJECTS: One-hundred and twenty mothers and 11 available types of infant formulas for term infants.
designWe analysed the fatty acid composition of colostrum (n=40), transitional milk (n=40), mature milk (n=40) and 11 infant formulas. We also analysed the fatty acid composition at sn-2 position in colostrum (n=12), transitional milk (n=12), mature milk (n=12), and the 11 infant formulas.
resultsHuman milk in Spain had low saturated fatty acids, high monounsaturated fatty acids and high linolenic acid. Infant formulas and mature human milk had similar fatty acid composition. In mature milk, palmitic acid was preferentially esterified at the sn-2 position (86.25%), and oleic and linoleic acids were predominantly esterified at the sn-1,3 positions (12.22 and 22.27%, respectively, in the sn-2 position). In infant formulas, palmitic acid was preferentially esterified at the sn-1,3 positions and oleic and linoleic acids had higher percentages at the sn-2 position than they do in human milk.
conclusionFatty acid composition of human milk in Spain seems to reflect the Mediterranean dietary habits of mothers. Infant formulas resemble the fatty acid profile of human milk, but the distribution of fatty acids at the sn-2 position is markedly different.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.