ArticleInternational journal of impotence research2002
Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle.
Article in International journal of impotence research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 21 citations in OpenAlex.
- Commentary on "Relationship between dietary niacin intake and erectile dysfunction: a population-based study".Asian journal of andrology · 2024Article
- Prostaglandin DJournal of cellular and molecular medicine · 2017Article
- Filtration markers may have prognostic value independent of glomerular filtration rate.Journal of the American Society of Nephrology : JASN · 2012Article
- In vitro models: research in physiology and pharmacology of the lower urinary tract.British journal of pharmacology · 2006Review
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8 authors at 2 institutions in 1 country.
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Abstract
Prostaglandin D(2) (PGD(2)) binds to specific G-protein coupled receptors (DP) and induces smooth muscle relaxation by stimulating the synthesis of intracellular cAMP. In this study, we examined the role of PGD(2) and DP receptors in regulating human penile smooth muscle contractility. We determined that human corpus cavernosum tissue and smooth muscle cells in culture expressed functional DP receptor and lipocalin-like prostaglandin D synthase by reverse-transcribed polymerase chain reaction (RT-PCR). Functional PGD synthase activity was confirmed by the synthesis of PGD(2) in human corpus cavernosum smooth muscle cells upon addition of exogenous arachidonic acid. Organ bath preparations of human corpus cavernosum tissue strips, contracted with phenylephrine, relaxed in a dose-dependent fashion to either PGD(2) or the DP selective agonist BW245C. Cultures of human corpus cavernosum smooth muscle cells treated with BW245C showed a two-fold increase in cAMP synthesis. These data are consistent with the expression of functional DP receptors in human corpus cavernosum. This suggests the presence of an intact prostanoid autocrine system that may play a role in regulating penile erectile function.
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