ArticleNucleic acids research2002
The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- LMTK2 switches on canonical TGF-β1 signaling in human bronchial epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Activation of Nm23-H1 to suppress breast cancer metastasis via redox regulation.Experimental & molecular medicine · 2021Review
- The CINs of Polo-Like Kinase 1 in Cancer.Cancers · 2020Review
- A competitive cell-permeable peptide impairs Nme-1 (NDPK-A) and Prune-1 interaction: therapeutic applications in cancer.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Transcriptional factor FOXO3 negatively regulates the expression of nm23-H1 in non-small cell lung cancer.Thoracic cancer · 2016Article
- Aurora-A Kinase as a Promising Therapeutic Target in Cancer.Frontiers in oncology · 2015Review
- Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene.Cancer metastasis reviews · 2012Review
- Protein-protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1.Naunyn-Schmiedeberg's archives of pharmacology · 2011Review
- Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Nm23-H1 can induce cell cycle arrest and apoptosis in B cells.Cancer biology & therapy · 2010Article
- Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.BMC cancer · 2009Article
- Regulators affecting the metastasis suppressor activity of Nm23-H1.Molecular and cellular biochemistry · 2009Review
- The NM23 family in development.Molecular and cellular biochemistry · 2009Review
- Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells.Journal of translational medicine · 2008Article
- Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1.Molecular biology of the cell · 2008Article
- Astrin regulates Aurora-A localization.Biochemical and biophysical research communications · 2008Article
- Translational approaches using metastasis suppressor genes.Journal of bioenergetics and biomembranes · 2006Review
- G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia.Oncogene · 2005Article
- Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells.Molecular and cellular biology · 2005Article
- Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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2 authors.
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Abstract
Alterations in the activity of the centrosomal kinase, Aurora-A/STK15, have been implicated in centrosome amplification, genome instability and cellular transformation. How STK15 participates in all of these processes remains largely mysterious. The activity of STK15 is regulated by phosphorylation and ubiquitin-mediated degradation, and physically interacts with protein phosphatase 1 (PP1) and CDC20. However, the precise roles of these modifications and interactions have yet to be fully appreciated. Here we show that STK15 associates with a putative tumor and metastasis suppressor, NM23-H1. STK15 and NM23 were initially found to interact in yeast in a two-hybrid assay. Association of these proteins in human cells was confirmed by co-immunoprecipitation from cell lysates and biochemical fractionation indicating that STK15 and NM23-H1 are present in a stable, physical complex. Notably, SKT15 and NM23 both localize to centrosomes throughout the cell cycle irrespective of the integrity of the microtubule network in normal human fibroblasts.
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