ArticleNucleic acids research2002
Helicobacter pylori interstrain restriction-modification diversity prevents genome subversion by chromosomal DNA from competing strains.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Xenogeneic Silencing and Bacterial Genome Evolution: Mechanisms for DNA Recognition Imply Multifaceted Roles of Xenogeneic Silencers.Molecular biology and evolution · 2021Review
- Natural Transformation ofFrontiers in microbiology · 2021Article
- N4-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pylori.Nucleic acids research · 2018Article
- Phylogeographic diversity and mosaicism of theMobile DNA · 2018Article
- Methylation-dependent DNA discrimination in natural transformation ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori.Nature communications · 2016Article
- The complex methylome of the human gastric pathogen Helicobacter pylori.Nucleic acids research · 2014Article
- The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts.Nucleic acids research · 2014Article
- A comparative analysis of methylome profiles of Campylobacter jejuni sheep abortion isolate and gastroenteric strains using PacBio data.Frontiers in microbiology · 2014Article
- Phylogeographic evidence of cognate recognition site patterns and transformation efficiency differences in H. pylori: theory of strain dominance.BMC microbiology · 2013Article
- Natural transformation of an engineered Helicobacter pylori strain deficient in type II restriction endonucleases.Journal of bacteriology · 2012Article
- Biochemical and cellular characterization of Helicobacter pylori RecA, a protein with high-level constitutive expression.Journal of bacteriology · 2011Article
- Defining the plasmid-borne restriction-modification systems of the Lyme disease spirochete Borrelia burgdorferi.Journal of bacteriology · 2011Article
- Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter-strain DNA recombination.Molecular microbiology · 2011Article
- Recombination and DNA repair in Helicobacter pylori.Annual review of microbiology · 2011Review
- Article
- Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer.Nucleic acids research · 2010Article
- Composite system mediates two-step DNA uptake into Helicobacter pylori.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Response of gastric epithelial progenitors to Helicobacter pylori Isolates obtained from Swedish patients with chronic atrophic gastritis.The Journal of biological chemistry · 2009Article
- Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration.BMC microbiology · 2009Article
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4 authors.
Funding
Abstract
Helicobacter pylori, bacteria that colonize the human gastric mucosa, possess a large number of genes for restriction-modification (R-M) systems, and essentially, every strain possesses a unique complement of functional and partial R-M systems. Nearly half of the H.pylori strains studied possess an active type IIs R-M system, HpyII, with the recognition sequence GAAGA. Recombination between direct repeats that flank the R-M cassette allows for its deletion whereas strains lacking hpyIIRM can acquire this cassette through natural transformation. We asked whether strains lacking HpyII R-M activity can acquire an active hpyIIRM cassette [containing a 1.4 kb kanamycin resistance (aphA) marker], whether such acquisition is DNase sensitive or resistant and whether restriction barriers limit acquisition of chromosomal DNA. Our results indicate that natural transformation and conjugation-like mechanisms may contribute to the transfer of large (4.8 kb) insertions of chromosomal DNA between H.pylori strains, that inactive or partial R-M systems can be reactivated upon recombination with a functional allele, consistent with their being contingency genes, and that H.pylori R-M diversity limits acquisition of chromosomal DNA fragments of >/=1 kb.
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