ArticleNucleic acids research2002
Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis.Development (Cambridge, England) · 2025Article
- Specialized ribosomes: integrating new insights and current challenges.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains.Nucleic acids research · 2024Article
- Specialized Ribosomes in Health and Disease.International journal of molecular sciences · 2023Review
- Integrated bioinformatics analysis of the transcription factor-mediated gene regulatory networks in the formation of spermatogonial stem cells.Frontiers in physiology · 2022Article
- Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.iScience · 2021Article
- Sequence variation, common tissue expression patterns and learning models: a genome-wide survey of vertebrate ribosomal proteins.NAR genomics and bioinformatics · 2020Article
- Review
- Quick, Coordinated and Authentic Reprogramming of Ribosome Biogenesis during iPSC Reprogramming.Cells · 2020Article
- An Investigation of ZZ/ZW and XX/XY Sex Determination Systems in North African Catfish (Frontiers in genetics · 2020Article
- Article
- Protein-Coding Genes' Retrocopies and Their Functions.Viruses · 2017Review
- Sex chromosome-to-autosome transposition events counter Y-chromosome gene loss in mammals.Genome biology · 2015Article
- The chromatin regulator Brpf1 regulates embryo development and cell proliferation.The Journal of biological chemistry · 2015Article
- Lyar, a cell growth-regulating zinc finger protein, was identified to be associated with cytoplasmic ribosomes in male germ and cancer cells.Molecular and cellular biochemistry · 2014Article
- Evolutionarily diverged regulation of X-chromosomal genes as a primal event in mouse reproductive isolation.PLoS genetics · 2014Article
- Article
- Article
- Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.Chemico-biological interactions · 2013Article
- Detecting transcription of ribosomal protein pseudogenes in diverse human tissues from RNA-seq data.BMC genomics · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a new class of ribosomal protein (RP) genes that appear to have been retrotransposed from X-linked RP genes. Mammalian ribosomes are composed of four RNA species and 79 different proteins. Unlike RNA constituents, each protein is typically encoded by a single intron- containing gene. Here we describe functional autosomal copies of the X-linked human RP genes, which we designated RPL10L (ribosomal protein L10-like gene), RPL36AL and RPL39L after their progenitors. Because these genes lack introns in their coding regions, they were likely retrotransposed from X-linked genes. The identities between the retrotransposed genes and the original X-linked genes are 89-95% in their nucleotide sequences and 92-99% in their amino acid sequences, respectively. Northern blot and PCR analyses revealed that RPL10L and RPL39L are expressed only in testis, whereas RPL36AL is ubiquitously expressed. Although the role of the autosomal RP genes remains unclear, they may have evolved to compensate for the reduced dosage of X-linked RP genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.