ArticleJournal of anatomy2002
Recombinant human alpha-2a interferon promotes an atypical process of mast cell secretion with ultrastructural features suggestive for piecemeal degranulation.
Article in Journal of anatomy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue.Bioactive materials · 2025Article
- Mast cell-nerve interaction in the colon of Trypanosoma cruzi-infected individuals with chagasic megacolon.Parasitology research · 2018Article
- Mechanisms of eosinophil cytokine release.Memorias do Instituto Oswaldo Cruz · 2005Review
- The distribution of mast cells in the human area postrema.Journal of anatomy · 2004Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purified mast cells (MC), isolated from the rat peritoneum, were stimulated in vitro with recombinant human IFN-alpha 2a (rhIFN-alpha 2a) and studied ultrastructurally. Quantitative determination of histamine release was also performed. The following ultrastructural features were observed: (1) dilation of single granules, leading to the formation of cytoplasmic cavities filled with dissolved or eroded matrices; (2) induction of partially empty, nonfused granule containers close to unaltered resting granules, a process very suggestive of piecemeal degranulation; (3) focal exocytosis, characterized by opening of single granules to the cell exterior and/or fusion of a few granules into small secretory channels. Histamine release was slightly increased in rhIFN-alpha 2a-treated MC, although not to significant levels. These results indicate that rhIFN-alpha 2a induces a characteristic pattern of degranulation in rat peritoneal MC and that a small proportion of rhIFN-alpha 2a-stimulated MC shows ultrastructural features suggestive for piecemeal degranulation.
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Registered trials
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