ArticleAmerican journal of human genetics2003
Distribution patterns of postmortem damage in human mitochondrial DNA.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Genetic diversity of the Y-chromosome in domestic animals: from evolutionary insights to functional implications.Molecular biology reports · 2025Review
- A Post-Mortem Molecular Damage Profile in the Ancient Human Mitochondrial DNA.Molecular ecology resources · 2025Article
- Verification of the family tree of the Makino family of the Nagaoka domain by DNA analysis.Anthropological science : journal of the Anthropological Society of Nippon = Jinruigaku zasshi · 2025Article
- Age estimation of burnt human remains through DNA methylation analysis.International journal of legal medicine · 2025Article
- An easy-to-use pipeline to analyze amplicon-based Next Generation Sequencing results of human mitochondrial DNA from degraded samples.PloS one · 2024Article
- Article
- Competitive mapping allows for the identification and exclusion of human DNA contamination in ancient faunal genomic datasets.BMC genomics · 2020Article
- Article
- Corded Ware cultural complexity uncovered using genomic and isotopic analysis from south-eastern Poland.Scientific reports · 2020Article
- Review
- Article
- Ethnic derivation of the Ainu inferred from ancient mitochondrial DNA data.American journal of physical anthropology · 2018Article
- Article
- Malaria was a weak selective force in ancient Europeans.Scientific reports · 2017Article
- The study of human Y chromosome variation through ancient DNA.Human genetics · 2017Review
- Article
- The earliest maize from San Marcos Tehuacán is a partial domesticate with genomic evidence of inbreeding.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Toward high-resolution population genomics using archaeological samples.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Review
- Differential nuclear and mitochondrial DNA preservation in post-mortem teeth with implications for forensic and ancient DNA studies.PloS one · 2015Article
- Maternal ancestry and population history from whole mitochondrial genomes.Investigative genetics · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
The distribution of postmortem damage in mitochondrial DNA retrieved from 37 ancient human DNA samples was analyzed by cloning and was compared with a selection of published animal data. A relative rate of damage (rho(v)) was calculated for nucleotide positions within the human hypervariable region 1 (HVR1) and cytochrome oxidase subunit III genes. A comparison of damaged sites within and between the regions reveals that damage hotspots exist and that, in the HVR1, these correlate with sites known to have high in vivo mutation rates. Conversely, HVR1 subregions with known structural function, such as MT5, have lower in vivo mutation rates and lower postmortem-damage rates. The postmortem data also identify a possible functional subregion of the HVR1, termed "low-diversity 1," through the lack of sequence damage. The amount of postmortem damage observed in mitochondrial coding regions was significantly lower than in the HVR1, and, although hotspots were noted, these did not correlate with codon position. Finally, a simple method for the identification of incorrect archaeological haplogroup designations is introduced, on the basis of the observed spectrum of postmortem damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.