ArticleJournal of biomedicine & biotechnology2002
Nucleotide Excision Repair, Genome Stability, and Human Disease: New Insight from Model Systems.
Article in Journal of biomedicine & biotechnology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- miRNA dysregulation is an emerging modulator of genomic instability.Seminars in cancer biology · 2021Review
- Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis.Neurobiology of sleep and circadian rhythms · 2020Review
- DNA repair defects and implications for immunotherapy.The Journal of clinical investigation · 2018Review
- Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.PloS one · 2012Article
- Base excision repair and the role of MUTYH.Hereditary cancer in clinical practice · 2007Article
- Article
- DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility.Molecular and cellular biology · 2007Article
- UvrD helicase suppresses recombination and DNA damage-induced deletions.Journal of bacteriology · 2006Article
- The DNA repair genes XPB and XPD defend cells from retroviral infection.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Retroviruses and yeast retrotransposons use overlapping sets of host genes.Genome research · 2005Article
- Article
- Comparative evaluation of XPD and XPG gene polymorphism in oral squamous cell carcinoma and tobacco chewers: An observational study.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Nucleotide excision repair (NER) is one of several DNA repair pathways that are universal throughout phylogeny. NER has a broad substrate specificity and is capable of removing several classes of lesions to the DNA, including those that accumulate upon exposure to UV radiation. The loss of this activity in NER-defective mutants gives rise to characteristic sensitivities to UV that, in humans, is manifested as a greatly elevated sensitivity to exposure to the sun. Xeroderma pigmentosum (XP), Cockaynes syndrome (CS), and trichothiodystrophy (TTD) are three, rare, recessively inherited human diseases that are linked to these defects. Interestingly, some of the symptoms in afflicted individuals appear to be due to defects in transcription, the result of the dual functionality of several components of the NER apparatus as parts of transcription factor IIH (TFIIH). Studies with several model systems have revealed that the genetic and biochemical features of NER are extraordinarily conserved in eukaryotes. One system that has been studied very closely is the budding yeast Saccharomyces cerevisiae. While many yeast NER mutants display the expected increases in UV sensitivity and defective transcription, other interesting phenotypes have also been observed. Elevated mutation and recombination rates, as well as increased frequencies of genome rearrangement by retrotransposon movement and recombination between short genomic sequences have been documented. The potential relevance of these novel phenotypes to disease in humans is discussed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.