ArticleThe Journal of clinical investigation2002
Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Sex-specific effects of 17-β-estradiol and bisphenol A on neutrophil function and phenotype - does centrifugation matter?Biology of sex differences · 2026Article
- Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer.Journal for immunotherapy of cancer · 2025Article
- Not just sugar: metabolic control of neutrophil development and effector functions.Journal of leukocyte biology · 2024Review
- The pentose phosphate pathway in health and disease.Nature metabolism · 2023Review
- Using Machine Vision of Glycolytic Elements to Predict Breast Cancer Recurrences: Design and Implementation.Metabolites · 2022Review
- Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Maternal Immunological Adaptation During Normal Pregnancy.Frontiers in immunology · 2020Review
- Effect of intra-cellular trafficking on flow cytometric measurement of neutrophil's oxidative status in iron deficient pregnant females.Journal of clinical laboratory analysis · 2018Article
- Multimodal Regulation of NET Formation in Pregnancy: Progesterone Antagonizes the Pro-NETotic Effect of Estrogen and G-CSF.Frontiers in immunology · 2016Article
- Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway.Frontiers in immunology · 2015Review
- Article
- An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase.Oncoimmunology · 2013Article
- Leukocyte pyruvate kinase expression is reduced in normal human pregnancy but not in pre-eclampsia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2010Article
- Leukocytes are primed in peripheral blood for activation during term and preterm labour.Molecular human reproduction · 2009Article
- Oscillatory NAD(P)H waves and calcium oscillations in neutrophils? A modeling study of feasibility.Biophysical journal · 2009Article
- Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies.Oncogene · 2008Review
- The remission of rheumatoid arthritis during pregnancy.Seminars in immunopathology · 2007Review
- Elevated glucose concentrations promote receptor-independent activation of adherent human neutrophils: an experimental and computational approach.Biophysical journal · 2007Article
- Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy.European journal of immunology · 2007Article
- The hexosamine biosynthesis pathway negatively regulates IL-2 production by Jurkat T cells.Cellular immunology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnancy is associated with changes in host susceptibility to infections and inflammatory disease. We hypothesize that metabolic enzyme trafficking affects maternal neutrophil activation. Specifically, immunofluorescence microscopy has shown that glucose-6-phosphate dehydrogenase (G-6-PDase), the rate-controlling step of the hexose monophosphate shunt (HMS), is located near the cell periphery in control neutrophils but is found near the microtubule-organizing centers in cells from pregnant women. Cytochemical studies confirmed that the distribution of the G-6-PDase antigen is coincident with functional G-6-PDase activity. Metabolic oscillations within activated pregnancy neutrophils are higher in amplitude, though lower in frequency, than activated control neutrophils, suggesting limited HMS activity. Analysis of radioisotope-labeled carbon flux from glucose to CO(2) indicates that the HMS is intact in leukocytes from pregnant women, but its level is not enhanced by cell stimulation. Using extracellular fluorescent markers, activated pregnancy neutrophils were found to release reactive oxygen metabolites (ROMs) at a lower rate than activated control neutrophils. However, basal levels of ROM production in polarized pregnancy neutrophils were greater than in control neutrophils. Microtubule-disrupting agents reversed the observed changes in G-6-PDase trafficking, metabolic oscillations, and ROM production by maternal neutrophils. G-6-PDase trafficking appears to be one mechanism regulating ROM production by maternal neutrophils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.