ArticleThe British journal of ophthalmology2003
Polymerase chain reaction analysis of aqueous humour samples in necrotising retinitis.
Article in The British journal of ophthalmology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 171 citations in OpenAlex.
- Article
- Acute Retinal Necrosis in an Infant With Corneal and Macular Scarring.Journal of vitreoretinal diseases · 2026Article
- Clinical Assessment of a Highly Multiplexed Panel Assay for the Diagnosis of Infectious Uveitis.American journal of ophthalmology · 2026Article
- The Use of CSF Multiplex PCR Panel in Patients with Viral Uveitis.Diagnostics (Basel, Switzerland) · 2026Article
- Preliminary exploration of metagenomic sequencing for pathogenic identification in infectious uveitis.Journal of ophthalmic inflammation and infection · 2024Article
- Long-Term Functional Outcomes of Retinal Detachment Due to Acute Retinal Necrosis: A Case Series.Biomedicines · 2024Article
- False negative result of polymerase chain reaction in very early stages of acute retinal necrosis.Journal of ophthalmic inflammation and infection · 2023Article
- First-line management of necrotizing herpetic retinitis by prioritizing the investigation of immune status and prognostic factors for poor visual outcomes.International ophthalmology · 2023Article
- An All-in-One Highly Multiplexed Diagnostic Assay for Rapid, Sensitive, and Comprehensive Detection of Intraocular Pathogens.American journal of ophthalmology · 2023Article
- Long-term follow-up of acute retinal necrosis with retinal detachment secondary to herpes simplex virus type 2 with a successful visual outcome.BMJ case reports · 2023Article
- Association Between Prognosis of Acute Retinal Necrosis and Retinal Involvement.Turkish journal of ophthalmology · 2022Article
- An atypical case of viral panuveitis and retinal vasculitis with retrograde extension associated with human herpesvirus-6.American journal of ophthalmology case reports · 2022Article
- Clinical and Virological Characteristics and Prognostic Factors in Viral Necrotizing Retinitis.Journal of personalized medicine · 2022Article
- Clinical spectrum, disease course and management outcome of post-fever retinitis cases: experience from a tertiary eye institute in central India.International ophthalmology · 2022Article
- Advances in the microbiological diagnosis of herpetic retinitis.Frontiers in ophthalmology · 2022Review
- Acute Retinal Necrosis: Clinical Features, Diagnostic Pitfalls, Treatment, and Outcome of an Insidious Disease in Children. Case Report and Review of the Literature.Frontiers in pediatrics · 2022Article
- Practical use of multiplex and broad-range PCR in ophthalmology.Japanese journal of ophthalmology · 2021Review
- Pars plana vitrectomy in uveitis in the era of microincision vitreous surgery.Indian journal of ophthalmology · 2020Review
- Acute retinal necrosis following dexamethasone intravitreal implant (Ozurdex®) administration in an immunocompetent adult with a history of HSV encephalitis: a case report.BMC ophthalmology · 2020Article
- Clinical utility of aqueous humor polymerase chain reaction and serologic testing for suspected infectious uveitis: a single-center retrospective study in South Korea.BMC ophthalmology · 2020Observational
3 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the diagnostic value of polymerase chain reaction (PCR) performed on aqueous humour for the detection of viral DNA in patients with necrotising herpetic retinitis.
methodsThe clinical features and laboratory results of 22 patients (29 eyes) presenting with necrotising herpetic retinitis between March 1999 and June 2001 were reviewed retrospectively. Aqueous humour was obtained after anterior chamber paracentesis and PCR was performed in all cases.
resultsViral DNA was detected in the aqueous humour of 19 patients (86.4%). Epstein-Barr virus (EBV) seroconversion was evidenced in one additional patient. In the acute retinal necrosis (ARN) group (n = 19), varicella zoster virus (VZV) DNA was identified in six patients, herpes simplex virus 1 (HSV-1) DNA in two patients, herpes simplex virus 2 (HSV-2) DNA in four patients, and cytomegalovirus (CMV) genome in four patients. In the progressive outer retinal necrosis (PORN) group (n = 3), VZV DNA was detected in all patients. No sample was positive for more than one virus.
conclusionsPCR analysis of aqueous humour in patients with clinical features of necrotising viral retinitis can provide specific aetiological orientation and the method appears to be safe and highly sensitive.
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