ArticleGenes and immunity2002
Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Complement receptor 1 variants confer protection from severe malaria in Odisha, India.PloS one · 2012Pooled it
- Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria.Haematologica · 2014Trial
- Elucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome.Nature communications · 2023Article
- Population-specific positive selection on low CR1 expression in malaria-endemic regions.PloS one · 2023Article
- Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytes.Scientific reports · 2019Article
- Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations.Communications biology · 2019Article
- No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.Scientific reports · 2017Article
- High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment.Journal of visualized experiments : JoVE · 2017Article
- Red blood cell complement receptor one level varies with Knops blood group, α(+)thalassaemia and age among Kenyan children.Genes and immunity · 2016Article
- Association of the single-nucleotide polymorphism and haplotype of the complement receptor 1 gene with malaria.Yonsei medical journal · 2015Article
- Extensive genomic variability of knops blood group polymorphisms is associated with sickle cell disease in Africa.Evolutionary bioinformatics online · 2015Article
- Human genetic polymorphisms in the Knops blood group are not associated with a protective advantage against Plasmodium falciparum malaria in Southern Ghana.Malaria journal · 2013Article
- The host genetic diversity in malaria infection.Journal of tropical medicine · 2012Article
- Article
- Evidence for malaria selection of a CR1 haplotype in Sardinia.Genes and immunity · 2011Article
- Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention.Current opinion in hematology · 2009Review
- Complement Receptor 1: disease associations and therapeutic implications.Molecular immunology · 2009Review
- Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics.Human genetics · 2008Review
- Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene.International journal of immunogenetics · 2006Article
- Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya.Malaria journal · 2005Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Complement receptor 1 (CR1) expression level on erythrocytes is genetically determined, and in Caucasian populations is linked to high (H) and low (L) expression alleles identified by a HindIII restriction fragment length polymorphism (RFLP). Erythrocyte CR1 may be an important factor in determining malaria susceptibility, as low expression of CR1 reduces the rosetting of uninfected erythrocytes with Plasmodium falciparum-infected cells, a process that contributes to malaria pathogenesis. Prior to studying CR1 expression and malaria susceptibility, we have investigated whether the quantity of erythrocyte CR1 correlates with the H and L alleles in an African population. Mean erythrocyte CR1 in 149 Malian adults was 415 molecules per cell, which is comparable to Caucasian populations; however, there was no relationship between erythrocyte CR1 level and genotype for the HindIII RFLP (mean CR1 per erythrocyte HH = 414, HL = 419 and LL = 403, P > 0.1, Student's t-test). The conclusions of a previous study of erythrocyte CR1 expression level and malaria susceptibility in West Africa that was based on HindIII RFLP genotyping may therefore need to be re-evaluated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.